Fibroblastic Foci - CHEST
In this more recent paradigm, the concept was advanced that the earliest and possibly only morphologic change that was associated with progression to more established fibrosis was the presence and extent of fibroblastic foci. In other words, the importance of fibroblastic foci at the center of the pathogenetic process was emphasized.
Three-dimensional characterization of fibroblast foci in idiopathic ...
Our results showed that, in 3D, foci in proximity and typically with shared areas of established fibrosis form one complex discrete fibroblast structure. A heterogeneous population was identified with large variations in size and shape and over a 100-fold difference between largest and smallest volume fibroblast foci.
The UIP/IPF fibroblastic focus is a collagen biosynthesis factory
2022年7月19日 · Here, we present a comprehensive molecular tissue atlas that defines cell surface and ECM proteins and conduct pathway analysis of histologically defined regions of the UIP/IPF lung in an effort to understand its pathogenesis. Spatial resolution of the UIP/IPF fibrotic front identifies distinct protein signatures.
Digital quantification of p16-positive foci in fibrotic interstitial ...
2022年6月7日 · We demonstrated the potential clinical applicability of a standardized quantification of p16-positive fibroblastic foci. This method identifies an IPF phenotype associated with foci-specific upregulation of senescence-associated and matrix remodeling gene expression.
Migratory marker expression in fibroblast foci of idiopathic pulmonary ...
2006年6月30日 · Fibroblast foci (FF) are considered a relevant morphologic marker of idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), and are recognised as sites where fibrotic responses are initiated and/or perpetuated in this severe disease.
Spatially distinct molecular patterns of gene expression in …
2023年11月17日 · We compared normal-appearing lung parenchyma and airways between IPF and controls with histologically normal lung tissue, as well as histologically distinct regions within IPF (normal-appearing lung parenchyma, transition zones containing fibroblastic foci, areas of dense fibrosis, and honeycomb epithelium metaplasia).
Transcriptome analysis of IPF fibroblastic foci identifies key …
The aim of this study was to define the major transcriptional programmes involved in fibrogenesis in IPF by profiling unmanipulated myofibroblasts within fibrotic foci in situ by laser capture microdissection.
Three-dimensional characterization of fibroblast foci in …
2016年4月21日 · In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are considered small, distinct lesions, although they have been proposed to form a highly interconnected reticulum …
Transcriptome analysis of IPF fibroblastic foci identifies
2020年3月11日 · Fibroblastic foci (FF) represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple fibrotic conditions.
Pathology Outlines - UIP / IPF
2023年3月21日 · There appears to be a temporally variegated appearance, with areas of relatively uninvolved lung, along with areas showing patchy interstitial fibrosis. Fibroblast foci are frequently identified. Mild chronic inflammatory infiltrate is noted. There is no evidence of opportunistic microorganisms, granulomatous inflammation and vasculitis.
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