Fibroblasts in Focus | American Journal of Respiratory and Critical ...
2006年6月12日 · The term fibroblast foci refers to the discrete, microscopic, subepithelial zones of acute lung injury characteristic of usual interstitial pneumonia (UIP). The term was first applied to human lungs in an ultrastructural description of localized epithelial necrosis and alveolar septal collapse in UIP/IPF ( 1 ).
Three-dimensional characterization of fibroblast foci in idiopathic ...
In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are considered small, distinct lesions, although they have been proposed to form a highly interconnected reticulum as the leading edge of a “wave” of fibrosis.
Fibroblasts: Origins, definitions, and functions in health and disease
2021年7月22日 · We summarize their development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart. We propose that fibroblasts are uniquely poised for tissue repair by easily reentering the cell cycle and exhibiting a reversible plasticity in phenotype and cell fate.
Fibroblastic Foci - CHEST
The fibrotic zones are composed mainly of dense collagen, although scattered foci of proliferating fibroblasts (so-called fibroblastic foci) are a consistent finding.
Three-dimensional characterization of fibroblast foci in
2016年4月21日 · In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are considered small, distinct lesions, although they have been proposed to form a highly interconnected reticulum …
The UIP/IPF fibroblastic focus is a collagen biosynthesis factory ...
2022年8月22日 · Usual interstitial pneumonia (UIP) is a histological pattern characteristic of idiopathic pulmonary fibrosis (IPF). The UIP pattern is patchy with histologically normal lung adjacent to dense fibrotic tissue. At this interface, fibroblastic foci (FF) are present and are sites where myofibroblasts and extracellular matrix (ECM) accumulate.
Fibroblast Foci Are Not Discrete Sites of Lung Injury or Repair
2006年9月9日 · A fibroblast focus of UIP, uninvolved (normal) lung, and a Masson body of COP, are presented after digestion by HhaI. In UIP and COP, two parental alleles are present after HhaI digestion representing the balanced methylation pattern and a polyclonal population of cells.
The term fibroblast foci refers to the discrete, microscopic, sube-pithelial zones of acute lung injury characteristic of usual intersti-tial pneumonia (UIP). The term was first applied to human lungs in an ultrastructural description of localized epithelial necrosis and alveolar septal collapse in …
(PDF) Three-dimensional characterization of fibroblast foci in ...
2016年4月21日 · In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are...
The UIP/IPF fibroblastic focus is a collagen biosynthesis factory
2022年7月19日 · At this interface, fibroblastic foci (FF) are present and are sites where myofibroblasts and extracellular matrix (ECM) accumulate. Utilizing laser capture microdissection-coupled mass spectrometry, we interrogated the FF, adjacent mature scar, and adjacent alveoli in 6 fibrotic (UIP/IPF) specimens plus 6 nonfibrotic alveolar specimens as controls.
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