Epithelial barrier biology: good fences make good neighbours
Epithelial surfaces are more than simple physical obstructions; they constitute complex chemical and biological obstacles. The acidity of the stomach and the mucus lining, as well as microbicidal enzymes in the gastrointestinal tract are often sufficient to prevent microbial invasion.
Mechanisms regulating intestinal barrier integrity and its …
2018年8月16日 · Epithelial cells form a layer that functions as a physical barrier facilitated by tight connections between each cell. A number of tight junction protein components seal the paracellular pathway...
Intestinal epithelial cells: regulators of barrier function ... - Nature
2014年2月25日 · Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. Secretory IECs support...
Paracellular permeability and tight junction regulation in gut …
2023年4月25日 · Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight junctions via two distinct size-selective and charge-selective...
Epithelial Cells: Structure, Transport, and Barrier Function
2015年1月1日 · Using the intestinal epithelium as an example, this chapter explores the regulation of epithelial barrier function in physiological and pathophysiological conditions and the intersection between intestinal paracellular permeability and mucosal immunity.
Intestinal Barrier Function: Molecular Regulation and Disease ...
The intestinal epithelial barrier is maintained by complex protein-protein networks that form desmosomes, adherens junctions and tight junctions (TJs). Alterations of TJ protein formation and distribution and/or destabilization of the TJ complexes …
Integrity of the Intestinal Barrier: The Involvement of Epithelial ...
In this review, we highlight the role of specific epithelial cell subtypes and their role in barrier arrangement, the mechanisms employed by them to control intestinal microbiota as well as the mechanisms utilized by the microbiome to regulate intestinal epithelial function.
The intestinal epithelial barrier: a therapeutic target? - PubMed
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as the intestinal microbiota, the underlying immune system and the remainder of the body, while supporting vectorial transport of …
The intestinal epithelial barrier: a therapeutic target? | Nature ...
2016年11月16日 · Here, we review and discuss mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases. We conclude...
The epithelial barrier: The gateway to allergic, autoimmune, and ...
2023年11月1日 · The epithelial barrier serves as the body's primary physical, chemical, and immunological barrier against external stimuli. A leaky epithelial barrier facilitates the translocation of the microbiome from the surface of the afflicted tissues to interepithelial and even deeper subepithelial locations.
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