Causes of lactic acidosis - UpToDate
2024年3月26日 · Lactic acidosis occurs when lactic acid production exceeds lactic acid clearance. The increase in lactate production is usually caused by impaired tissue oxygenation, either from decreased oxygen delivery or a defect in mitochondrial oxygen utilization.
Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus
Lactic acidosis occurs when lactate production exceeds its metabolism. There are many possible causes of lactic acidosis, and in any given patient, several causes may coexist. This Attending Rounds presents a case in point.
Lactic Acidosis - StatPearls - NCBI Bookshelf
2023年7月17日 · Patients with diabetes who are prescribed metformin should be educated by the pharmacist about the signs and symptoms of lactic acidosis. Even though rare, a change in medication is recommended. Outcomes
Lactic Acidosis: Symptoms, Causes, Treatment & What It Is
2023年6月13日 · Lactic acidosis is a type of metabolic acidosis that occurs when lactic acids build up in your blood. Your body produces more lactate when your tissues are deprived of oxygen. Lactate can also build up if your livers and kidneys aren’t able to metabolize it efficiently.
Lactic Acidosis: Causes, Symptoms, Treatment, and More
2024年4月25日 · Diabetic ketoacidosis (DKA) is a complication of diabetes resulting from inadequate insulin levels, a hormone that helps sugar enter cells. In DKA, metabolic disturbances increase lactate in the bloodstream.
The Phantom of Lactic Acidosis due to Metformin in Patients With Diabetes
2004年7月1日 · Metformin is associated with lactic acidosis in patients with conditions that can themselves cause lactic acidosis (heart failure, hypoxia, sepsis, etc.). But it is impossible to determine to what extent, if any, metformin may contribute to the development of lactic acidosis in any individual case.
Metformin-Associated Lactic Acidosis (MALA) - StatPearls - NCBI Bookshelf
2023年4月17日 · Metformin-associated lactic acidosis (MALA) is a rare complication of altered lactate and hydrogen metabolism defined as pH < 7.35 and lactate > 5.0 mmol/L in the setting of metformin use or overdose. Depending on the setting, it carries a mortality rate of up to 50%, which is correlated with worsening of acidosis and hyperlactatemia.
Lactic Acidosis: Symptoms, Causes, Treatment & More - Healthline
2022年3月16日 · In people with diabetes, lactic acidosis may be more of a concern if kidney disease is also present. If you have diabetes and experience any symptoms of lactic acidosis, call 911 or go to...
Hyperglycaemic crises and lactic acidosis in diabetes mellitus
2004年5月11日 · Diabetic ketoacidosis, hyperglycaemic hyperosmolar state, and lactic acidosis represent three of the most serious acute complications of diabetes.
Risk of Fatal and Nonfatal Lactic Acidosis With ... - JAMA Network
The objective of this review is to assess the risk of fatal and nonfatal lactic acidosis associated with metformin use in persons with type 2 diabetes mellitus compared with placebo or other glucose-lowering therapies.
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