DNA damage-induced cell death by apoptosis - PubMed
DNA damage-triggered signaling and execution of apoptosis is cell-type- and genotoxin-specific depending on the p53 (p63 and p73) status, death-receptor responsiveness, MAP-kinase activation and, most importantly, DNA repair capacity.
DNA damage-induced apoptosis | Oncogene - Nature
2004年4月12日 · Unicellular organisms respond to the presence of DNA lesions by activating cell cycle checkpoint and repair mechanisms, while multicellular animals have acquired the further option of eliminating...
DNA Damage Response and Apoptosis - PMC - PubMed Central …
DNA damage activates checkpoint mechanisms in mammalian cells that arrest cell cycle to allow time to repair the DNA damage, or if that is too severe to induce cell death, most commonly by apoptosis. Formation of foci of different nuclear proteins is a widely used method for assessing DNA double-strand breaks (DSB) formation and their repair.
DNA damage-induced cell death: from specific DNA lesions to the DNA …
2013年5月28日 · DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the …
DNA damage-induced apoptosis - PubMed
2004年4月12日 · Defects in DNA damage-induced apoptosis contribute to tumorigenesis and to the resistance of cancer cells to a variety of therapeutic agents. The intranuclear mechanisms that signal apoptosis after DNA damage overlap with those that initiate cell cycle arrest and DNA repair, and the early events in these pathways are highly conserved.
DNA damage and apoptosis | Cell Death & Differentiation - Nature
2001年10月30日 · The apoptotic function of p73 contributes to cell death induced by DNA damage, by E2F1, and by T-cell antigen receptor. 3,7,8 The p73 gene also encodes an anti-apoptosis protein, the ΔN-p73. 9,10...
DNA damage-induced cell death by apoptosis - Cell Press
During the last ten years, specific DNA lesions that trigger apoptosis have been identified. These include O 6 -methylguanine, base N-alkylations, bulky DNA adducts, DNA cross-links and DNA double-strand breaks (DSBs). Repair of these lesions are important in preventing apoptosis.
DNA damage-induced cell death: From specific DNA lesions to the DNA ...
2013年5月28日 · DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the …
DNA Damage-Induced Apoptosis | SpringerLink
2017年1月1日 · DNA damage–induced apoptosis is thought to be a mechanism protecting against cancer because it eliminates genetically damaged cells. This is most obvious in sun burned skin in which p53 upregulation initiates the apoptotic process in response to light-induced DNA damage.
Cell Death Response to DNA Damage - PMC - PubMed Central …
DNA damage-induced growth arrest can sustain life by blocking DNA replication and mitosis to avoid mitotic catastrophe. Without a doubt, the most important player that enables the apoptosis option in DDR is the transcription factor p53, encoded by the human TP53 gene, with orthologs in other vertebrate species.
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