Chemical stabilization strategy for cymoxanil: synthesis and ...
2024年7月19日 · Cymoxanil (CX), an essential fungicide, effectively controls fungal diseases but its environmental instability often leads to decreased efficacy and frequent applications, increasing costs and environmental risks. We propose to address this issue by cocrystal engineering, particularly, utilizing organic smal.
CN106588700A - Improved cymoxanil synthesis method
The invention discloses an improved cymoxanil synthesis method. Wastewater in the process can be recycled, so that the environmental protection pressure is greatly reduced; therefore, the...
Cymoxanil disrupts RNA synthesis through inhibiting the activity …
2024年5月22日 · We found that gene families related to de novo purine biosynthesis and ribonucleoside synthesis were enriched in the presence of CMX. These results were confirmed through additional spot-test and...
Cymoxanil: Synthesis and Characterization of Cocrystals with Small Organic Acids Mingzhu Yang a, Zhouyu Jiang , Cunbin Dub, Xiaowen Zhanga, Mingliang Wanga* a School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China b School of Pharmaceutical and Materials Engineering, Taizhou University, Taizhou,
WO2021250653A1 - Stable cymoxanil formulations - Google …
It has contact and local systemic activity and in the target pathogen, cymoxanil inhibits synthesis of nucleic acids, amino acids, and other cellular processes. Cymoxanil is highly soluble in...
Cymoxanil disrupts RNA synthesis through inhibiting the activity …
2024年5月22日 · Using qRT-PCR and expression assays, we found that CMX appears to target RNA biosynthesis possibly through the yeast dihydrofolate reductase (DHFR) enzyme Dfr1. To determine whether DHFR is a target of CMX, we performed an in-silico molecular docking assay between CMX and yeast, human, and P. infestans DHFR.
The agricultural fungicide cymoxanil (CMX) is commonly used in the treatment of plant pathogens, such as Phytophthora infestans. Although the use of CMX is widespread throughout the agricultural...
Cymoxanil disrupts RNA synthesis through inhibiting the activity …
2024年5月22日 · A model outlining how CMX interferes with the activity of DHFR, culminating in downstream effects and decreases in RNA synthesis. (a) Under normal conditions, DHFR converts dihydrofolate (DHF) to...
Cymoxanil disrupts RNA synthesis through inhibiting the activity …
We found that gene families related to de novo purine biosynthesis and ribonucleoside synthesis were enriched in the presence of CMX. These results were confirmed through additional spot-test and colony counting assays. We next examined whether CMX affects RNA biosynthesis.
Cymoxanil | C7H10N4O3 | CID 5364079 - PubChem
Cymoxanil is a member of the class of ureas that is urea in which the two nitrogen atoms are substituted by an ethyl group and a 2-cyano-2- (methoxyimino)acetyl group respectively. A fungicide used to control Peronosporales on a range of crops including vines, hops and potatoes.
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