Targeting integrin pathways: mechanisms and advances in …
Integrin α2β1 is expressed in fibroblasts, T cells, myeloid cells, megakaryocytes, platelets, keratinocytes, epithelial cells, and endothelial cells. 100,109 Integrin α2β1 binds with...
The role of integrins in inflammation and angiogenesis
2020年10月7日 · These integrins bind different ECM components, such as laminins, collagens, and fibronectin, and are known to coordinate epithelial cell adhesion and movement. 4,66 These integrins recognize...
Integrins: An Overview of Structural and Functional Aspects
Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion. 1 With their extracellular head region, most integrins bind extracellular matrix (ECM) glycoproteins such as laminins and collagens in basement membranes or connective tissue components like fibronectin.
Integrin adhesion complexes: Current Biology - Cell Press
2021年5月24日 · For example, the fibronectin-binding integrins α5β1 and αvβ3 show differential regulation of focal adhesions; α5β1 integrin promotes adhesion turnover and is enriched in nascent adhesions, while αvβ3 integrin stabilises adhesions and is …
The Molecular Interaction of Collagen with Cell Receptors for ...
As an abundant ECM protein, collagen possibly binds with at least five different groups of receptors in biological cells based on the available data. These are integrins, DDR, Glycoprotein VI, Osteoclast-associated receptor (OSCAR), LAIR-1, and uPARAP/Endo180.
Integrin trafficking in cells and tissues | Nature Cell Biology
2019年1月2日 · In fibroblasts, interaction between fibronectin and its receptor α 5 β 1 integrin promotes α 5 β 1 integrin ubiquitination and routing towards lysosomal trafficking and degradation.
Fibronectin‐Mediated Inflammatory Signaling Through Integrin …
2021年9月2日 · Adhesion of vascular endothelial cells to the underlying basement membrane potently modulates endothelial cells to cells' inflammatory activation. The normal basement membrane proteins laminin and collagen IV attenuate inflammatory signaling in …
The integrin–collagen connection – a glue for tissue repair?
2016年2月15日 · GPVI is an important collagen-binding immune receptor on platelets, with an activating role that is independent of integrin α2β1 (Marjoram et al., 2014; Zahid et al., 2012). Recent data suggest that it can also bind laminin isoforms …
Molecular Interactions between Collagen and Fibronectin: A …
2019年8月8日 · For instance, collagen (COL) assembly proceeds spontaneously in vitro yet is strongly reliant on fibronectin (FN) in vivo. To elucidate the potential FN-COL interactions during tissue genesis, we explore their co-dependence in vitro by investigating protein binding, conformational changes, assembly kinetics, co-localization, and fiber mechanics.
The gripping story of integrins - Cell Press
2022年10月13日 · The clear implication was that the cell surface membrane harbors a fibronectin receptor that integrates the extracellular matrix (represented by fibronectin) with the cytoplasm, specifically with the machinery responsible for cell shape and motility.
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