Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating …
2019年6月14日 · Codon-pair bias is thought to affect translational fidelity and efficiency and is presumed to be under the selective pressure. It was suggested that changes in codon-pair utilization may affect human disease more significantly than changes in single codons.
Synonymous but not the same: the causes and consequences of codon bias …
2010年11月23日 · Naturally occurring codon biases are pervasive, and they can be extremely strong. Some species such as Thermus thermophilus avoid certain codons almost entirely. Synonymous mutations are...
Bias at the third nucleotide of codon pairs in virus and host …
2022年3月16日 · Here we show that grouping codons of a codon-pair according to the GC content of the first two nucleotide positions of each codon reveals patterns in nucleotide usage at the third position of...
Codon Bias as a Means to Fine-Tune Gene Expression - PMC
In all domains of life, a biased frequency of synonymous codons is observed at the genome level, in functionally related genes (e.g., in operons), and within single genes. Other codon bias variants include biased codon pairs and codon co-occurrence.
Codon usage bias | Molecular Biology Reports - Springer
2021年11月25日 · Codon-usage bias is critical factor determining gene expression and cellular function by influencing diverse processes such as RNA processing, protein translation and protein folding. Codon usage bias reflects the origin, mutation patterns and evolution of the species or …
Synonymous but not the same: the causes and consequences of codon bias …
Codon bias plays a critical role in heterologous gene expression. However, there is often a disconnect between technological and evolutionary studies of codon bias – a gap that partly reflects genuine differences between endogenous and heterologous situations.
Virus Attenuation by Genome-Scale Changes in Codon Pair Bias
2008年6月27日 · A species-specific “codon pair bias” provides that some synonymous codon pairs are used more or less frequently than statistically predicted. We synthesized de novo large DNA molecules using hundreds of over-or underrepresented synonymous codon pairs to encode the poliovirus capsid protein.
Codon optimality, bias and usage in translation and mRNA decay
2017年10月11日 · The advent of ribosome profiling and other tools to probe mRNA translation has revealed that codon bias — the uneven use of synonymous codons in the transcriptome — serves as a secondary...
Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias
2016年1月5日 · Codon pair bias is a remarkably stable characteristic of a species. Although functionally uncharacterized, robust virus attenuation was achieved by recoding of viral proteins using underrepresented codon pairs.
Virus Attenuation by Genome-Scale Changes in Codon Pair Bias
2008年6月6日 · As a result of the redundancy of the genetic code, adjacent pairs of amino acids can be encoded by as many as 36 different pairs of synonymous codons. A species-specific “codon pair bias” provides that some synonymous codon pairs are used more or less frequently than statistically predicted.
- 某些结果已被删除