Circulating tumor cells in breast cancer: clinical validity ... - Nature
2024年11月29日 · Circulating tumor cells (CTCs) have been extensively studied in breast cancer (BC), with large studies establishing CTCs as a robust prognostic biomarker in early and metastatic breast cancer (MBC).
Circulating tumor cells: biology and clinical significance
2021年11月22日 · Single-cell sequencing of CTCs has been extensively investigated, and has enabled researchers to reveal the genome and transcriptome of CTCs. Herein, we also review the clinical applications of...
Circulating Tumor Cells in Early Breast Cancer - PMC
Circulating tumor cells (CTCs) are cancer cells that are detected in the patient’s blood. The development of robust and clinical study-friendly techniques has led to thorough investigation of CTCs as biomarkers in stageIV breast cancer, where CTCs can frequently be detected.
Circulating Tumor Cells in the Management of Breast Cancer
2009年7月10日 · There is growing evidence that circulating tumor cells (CTC) could help predict recurrence and effectiveness of therapy. However, there are unresolved issues with CTC detection methods and their implementation in the community. The utility of CTC testing in the management of breast cancer is unclear based on current studies.
Circulating tumour cells for early detection of clinically relevant cancer
2023年6月2日 · In this Perspective, we discuss the clinical significance of early haematogenous dissemination of cancer cells, the potential of CTCs to facilitate early detection of clinically relevant...
Circulating Tumor Cells in Breast Cancer: Correlation to Bone …
2005年5月16日 · Circulating tumor cell detection is linked to disease progression and elevated tumor marker concentrations in patients with metastatic breast cancer. Peripheral blood could be an ideal source for the detection of disseminated tumor cells due …
Circulating tumor cells: biology and clinical significance
2021年11月22日 · Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis. Detecting these very rare CTCs among the massive blood cells is challenging.
Circulating tumor cells in breast cancer: applications in
In this review, we discuss the clinical implications of CTC detection and its potential utility for personalized medicine in breast cancer. Over the past two decades, improved treatment options, including the emergence of new targeted therapies, have yielded better clinical outcomes for breast cancer patients [1].
Circulating Tumor Cells in Breast Cancer | SpringerLink
2023年1月26日 · Breast cancer metastasis is driven by genetic and/or phenotypic changes that occur in tumor cells, allowing them to leave primary site and spread through the body via the circulatory system. These circulating tumor cells (CTCs) may extravasate at secondary site and form metastases.
Circulating tumor cells in breast cancer: Advanced tools for ... - PNAS
In this issue of PNAS, Meng et al. raise interesting possibilities for exploring circulating tumor cells (CTCs) for personalizing targeted therapy of cancer in the future.