Mechlorethamine: Uses, Interactions, Mechanism of Action
Mechlorethamine is an antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia. A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Clinical Review - Chlormethine Gel (Ledaga) - NCBI Bookshelf
Chlormethine (mechlorethamine, also referred to as nitrogen mustard [NM]) is an alkylating agent that received its initial approval in the US for the topical treatment of MF in 1949.
Mechlorethamine | C5H11Cl2N | CID 4033 - PubChem
Mechlorethamine appears as a chemical warfare blister agent. Mobile liquid; faint odor of herring. Used as a drug for the treatment of cancer. Mechlorethamine is a nitrogen mustard and an organochlorine compound. It has a role as an alkylating agent. View More... 2-chloro- N - (2-chloroethyl)- N -methylethanamine.
Chlormethine - an overview | ScienceDirect Topics
Chlormethine (2-chloro-N-(2-chloroethyl)-N-methylethan-1-amine, mechlorethamine) is an alkylating agent that received its initial approval in the US for the topical treatment of MF in 1949. Its use in various compounded formulations has a long history documented in several uncontrolled studies [29–32] .
Management of Mycosis Fungoides with Topical Chlormethine ...
Topical chlormethine, otherwise known as mechlorethamine, was first introduced in the 1950s as an effective skin-directed chemotherapeutic agent for treating early-stage mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL) (1 – 4).
Chlormethine - an overview | ScienceDirect Topics
Among the toxic agents causing pulmonary responses, chlorine is a common and potent irritant inhalant accounting for substantial human morbidity. 15,76,77 Common forms of exposure include industrial leaks, 78,79 environmental releases primarily during transport, 80,81 water purification, 82 swimming pool–related events, 83,84 household cleaning ...
The PROVe Study: US Real-World Experience with Chlormethine ...
This real-world study confirmed that chlormethine gel is an important therapeutic option for patients with mycosis fungoides and contributes to reducing the severity of skin lesions and improving health-related quality of life.
Chlormethine - an overview | ScienceDirect Topics
Chlormethine is a medication that was previously used in combination with other drugs for the treatment of Hodgkin's disease, but has since been replaced by another medication. It works by binding to specific sites in DNA, which leads to the formation of …
Chlormethine: Uses, Dosage, Side Effects, FAQ - MedicinesFAQ
2023年9月19日 · Chlormethine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy.
Chlormethine Gel for Treatment of Patients with Mycosis
2024年11月27日 · Chlormethine gel is also an appropriate first-line monotherapy for patients with stage IB or IIA MF; it may be used as part of combination regimens in these patients as well. For patients with late-stage MF, skin-directed treatments such as chlormethine gel should be combined with systemic therapies. Chlormethine gel is a safe and effective ...
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