CGAS Gene - GeneCards | CGAS Protein | CGAS Antibody
2024年12月24日 · CGAS (Cyclic GMP-AMP Synthase) is a Protein Coding gene. Diseases associated with CGAS include Covid-19 and Severe Covid-19. Among its related pathways …
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
2021年4月30日 · cGAS (also known as C6orf150, or male abnormal 21 domain containing 1 (MAB21D1)) is located on chromosome 6q13 and encodes a protein with 522 amino acids in …
cGAS–STING cytosolic DNA sensing pathway - Wikipedia
The cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP Synthase triggers reaction of GTP and ATP to form …
The N-Terminal Domain of cGAS Determines Preferential ... - PubMed
2019年2月26日 · The non-enzymatic N-terminal domain of cGAS determines nucleo-cytoplasmic localization, enrichment on centromeres, and activation of nuclear-localized cGAS. These …
Structural mechanism of cytosolic DNA sensing by cGAS
2013年5月30日 · Recognition of cytosolic DNA by the recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of cGAMP to activate the stimulator of …
Analysis of human cGAS activity and structure - ScienceDirect
2019年1月1日 · The human cGAS protein is composed of a disordered N-terminus (amino acids 1–156) extended from a structured C-terminal domain (amino acids 157–522) that harbors …
Structural basis for sequestration and autoinhibition of cGAS by ...
2020年9月10日 · Cyclic GMP–AMP synthase (cGAS) is an innate immune sensor for cytosolic microbial DNA 1. After binding DNA, cGAS synthesizes the messenger 2′3′-cyclic GMP–AMP …
Current understanding of the cGAS-STING signaling pathway: …
The first E3 ubiquitin ligase identified for cGAS ubiquitination was ring finger protein 185 (RNF185), which contains a RING domain that interacts with cGAS. RNF185 specifically …
Crucial role of the cGAS N terminus in mediating flowable and ...
1 天前 · The DNA-sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid-liquid phase separation (LLPS) and …
cGAS-STING: mechanisms and therapeutic opportunities
The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA (dsDNA) in the cytoplasm and triggering downstream …
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