CDD Conserved Protein Domain Family: Ceramidase_alk
2022年10月17日 · This family represents N-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyses ceramide to generate sphingosine and fatty acid.
Structure of a human intramembrane ceramidase explains …
2018年12月21日 · We report here the crystal structure of the human ACER type 3 (ACER3). Together with computational studies, the structure reveals that ACER3 is an intramembrane enzyme with a seven transmembrane...
Ceramidase - an overview | ScienceDirect Topics
Ceramidase (CDase) is an enzyme that hydrolyzes the N-acyl linkage between the sphingoid base and fatty acid of ceramide. These enzymes are classified into three distinct groups, acid (Asah1), neutral (Asah2), and alkaline (Asah3) CDases, based on …
Ceramidases, roles in sphingolipid metabolism and in health and …
Thus far, five human ceramidases encoded by five different genes have been identified: acid ceramidase (AC), neutral ceramidase (NC), alkaline ceramidase 1 (ACER1), alkaline ceramidase 2 (ACER2), and alkaline ceramidase 3 (ACER3). These ceramidases are classified according to their optimal pH for catalytic activity.
ASAH1 Gene - GeneCards | ASAH1 Protein | ASAH1 Antibody
2024年10月1日 · This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
CDD Conserved Protein Domain Family: Ceramidase - National …
2022年10月17日 · Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST …
Neutral ceramidase: Advances in mechanisms, cell regulation, …
2019年1月1日 · The overall structure showed a catalytic domain (residues 99–626), a short linker (627–641), and an immunoglobulin (IG)-like domain (642–780). In comparison with the distantly homologous bacterial CDase (bCDase), in the human nCDase, a 30-residue subdomain insert replaces a 6-residue span of bCDase.
NCBI Conserved Domain Search - National Center for …
Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23. This family belongs to the CREST superfamily, which are distantly related to the GPCRs. Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51 (D)384-8.
Structural basis for the activation of acid ceramidase
2018年4月24日 · Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes. Abnormal function of aCDase...
New insight into the structure, reaction mechanism, and ... - PubMed
Ceramidase (CDase) is an enzyme that hydrolyzes the N-acyl linkage between the sphingoid base and fatty acid of ceramide. These enzymes are classified into three distinct groups, acid (Asah1), neutral (Asah2), and alkaline (Asah3) CDases, based on …