Colin C, Voutsinos-Porche B, Nanni I, Fina F, Metellus P, Intagliata D, et al. High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in...
了解详细信息：Colin C, Voutsinos-Porche B, Nanni I, Fina F, Metellus P, Intagliata D, et al. High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in...
www.nature.com/articles/s41419-023-05786-0Cathepsin B has been shown to be involved in the pathogenesis of pancreatitis, by prematurely activating the digestive enzyme trypsinogen within the pancreas, leading to autodigestion of acinar cells.
en.wikipedia.org/wiki/Cathepsin_BThis irreversible inhibitor displays nanomolar potency with 100-fold selectivity for inhibition of cathepsin B at pH 7.2 compared to pH 4.6, shows specificity for cathepsin B over other cysteine cathepsins, and is cell permeable and inhibits intracellular cathepsin B.
pubs.acs.org/doi/10.1021/acschembio.1c00138In cancer patients, elevated cathepsin B activity correlates to poor therapy outcome. Therefore, it is not surprising that the use of cathepsin B inhibitors reduces both tumor cell motility and invasiveness in vitro. This review summarizes recent developments in cathepsin B inhibition.
pubmed.ncbi.nlm.nih.gov/16918357/In recent years, the efforts of pharmacological research have been focused on targeting Cathepsin B specifically. For instance, the chemically designed Cathepsin B inhibitor ankyrin repeat protein DARP demonstrated more significant benefits for anti-cancer therapy and diagnostics.
www.sciencedirect.com/topics/medicine-and-dentis…Cathepsin B - Wikipedia
Cathepsin B has been shown to be involved in the pathogenesis of pancreatitis, by prematurely activating the digestive enzyme trypsinogen within the pancreas, leading to autodigestion of …
Selective Neutral pH Inhibitor of Cathepsin B Designed …
This irreversible inhibitor displays nanomolar potency with 100-fold selectivity for inhibition of cathepsin B at pH 7.2 compared to pH 4.6, shows specificity for cathepsin B over other cysteine cathepsins, and is cell permeable and inhibits …
Inhibitors of cathepsin B - PubMed
In cancer patients, elevated cathepsin B activity correlates to poor therapy outcome. Therefore, it is not surprising that the use of cathepsin B inhibitors reduces both tumor cell motility and …
Cathepsin B Inhibitor - an overview | ScienceDirect Topics
In recent years, the efforts of pharmacological research have been focused on targeting Cathepsin B specifically. For instance, the chemically designed Cathepsin B inhibitor ankyrin …
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Molecular Features of CA-074 pH-Dependent …
2022年2月5日 · The use of the selective cathepsin B inhibitor, CA-074, has facilitated studies of cathepsin B inhibition that ameliorates dysfunctional phenotypes in cell and animal models of human disease conditions.
Cathepsin B Inhibitor - an overview | ScienceDirect Topics
Cathepsin B inhibitor prevents neural death by lowering the cathepsin B release by exocytosis when assessed on mice. These research conclusions proved that inflammation is considered …
Cathepsin B: Active site mapping with peptidic substrates and …
2019年1月1日 · The development of potent and selective low-molecular cathepsin B inhibitors relies on the detailed expertise on preferred amino acid and inhibitor residues interacting with …
Inhibition of cathepsin B by caspase-3 inhibitors blocks ... - Nature
2016年4月8日 · We propose here that caspase-3 inhibitors reduce PCD in plants by targeted cathepsin B since a cathB1-2-3 triple mutant has a reduced PCD after treatment using …
Identification of Novel Cathepsin B Inhibitors with Implications in ...
2021年7月31日 · Cathepsin B inhibitors from natural sources have previously demonstrated cathepsin B enzyme inhibitory activity in vitro in the range of 0.62–1.17 μM . These studies …