Cell signalling in the cardiovascular system: an overview - PMC
This review gives an up to date coverage of the important GPCRs in cardiac cells, the intracellular signalling events associated with their activation, and the mechanisms involved in signal termination. The review focuses particularly on β adrenergic receptors.
Cardiac Signaling - Cardiovascular Signaling in Health and …
Intracellular Cardiac Signaling Pathways Altered by Cancer Therapies; Protein Phosphatase Signaling in Cardiac Myocytes; Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function; NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes; Lipid Mediators in Cardiovascular ...
Key Signaling Pathways in the Cardiovascular System
May 30, 2020 · In this chapter, the main signaling pathways activated in the heart in order to cope with the demands imposed to the cardiovascular system are described.
Signaling pathways and targeted therapy for myocardial …
Mar 10, 2022 · In this review, we summarize the therapeutic strategies for MI by regulating these associated pathways, which contribute to inhibiting cardiomyocytes death, attenuating inflammation, enhancing...
Cell Communications in the Heart | Circulation - AHA/ASA Journals
Aug 31, 2010 · Multiple intracellular signaling pathways and molecular effectors are involved in the regulation of cardiomyocyte hypertrophy, including G-protein isoforms, calcineurin, insulin-like growth factor (IGF)-I, fibroblast growth factors (FGFs), transforming growth factor (TGF)-β, Ras GTPases, mitogen-activated protein kinase cascades, histone ...
Cardiac and Vascular Receptors and Signal Transduction
Heart failure is generally characterized by dysfunction of the β-AR system (downregulation of β1-receptors, uncoupling of β-AR and AC) but also the renin-angiotensin system (downregulation of AT1 receptors); distinct signaling pathways have been identified which then characterizes both β-AR (e.g., via Gs and AC) and AT1 receptor signaling ...
Signaling Pathways in Cardiovascular Development
Jan 1, 2011 · The serendipitous discovery of the convergence of several signaling pathways that regulate endothelial proliferation and differentiation in developing and postnatal heart valves has provided insight into the roles played by highly conserved signaling elements including vascular endothelial growth factor (VEGF), NFATc1, Notch, Wnt/β-catenin ...
Signaling and Transcriptional Networks in Heart Development …
In the early heart, cells expressing cardiac markers coalesce at the midline of the embryos to form a linear heart tube that soon begins to contract. The linear heart tube expands and begins a series of contortions. This cardiac looping shifts the heart tube toward the right of the embryo, the first overt sign of breaking left–right symmetry.
Notch and interacting signalling pathways in cardiac ... - Nature
Oct 4, 2018 · In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in...
Endocardial Notch Signaling in Cardiac Development and Disease
Dec 3, 2015 · Data from several laboratories indicate that (1) the endocardium is a crucial source of signals that play key roles in cardiac development and disease; (2) the Notch pathway is a paradigmatic endocardial-derived signal, which regulates cell fate specification and tissue patterning in the early vertebrate heart to define chamber versus valve ...