EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac …
2020年3月5日 · In the present work, we demonstrate that knockdown of EHD1 impaired the internalization of Cx43, preserving gap junction-intercellular coupling in cardiomyocytes. Interaction of Cx43 with EHD1 was mediated by Eps15 and promoted by phosphorylation and ubiquitination of Cx43.
Role of Gap Junctions in Cardiac Conduction and Development
2000年9月1日 · In the heart, there are 3 major connexin isotypes expressed: connexin (Cx)43 (α 1 connexin), Cx45 (α 6 connexin), and Cx40 (α 5 connexin). Each of these connexins exhibits different channel properties and is regulated by different gating mechanisms.
Connexins in the Heart: Regulation, Function and Involvement in Cardiac ...
Cx43 is the main connexin isoform expressed in the working ventricular myocardium. In fact, Cx43 has been the most studied isoform with regard to its role in cardiac conduction. The involvement of Cx43 and gap junctions in ventricular conduction has been supported by computer simulations of microscopic impulse propagation.
Overexpression of Cx43 in cells of the myocardial scar: Correction …
2018年5月8日 · Cx43 was expressed in (myo)fibroblasts and CD45 + cells within the scar and provided prominent and long lasting arrhythmia protection in vivo. Optical mapping of Cx43 injected hearts revealed...
Gap junction protein Connexin-43 is a direct transcriptional
2018年9月21日 · We show that Connexin 43 (Cx43) controls neural crest cell migration in vivo by directly regulating N-cadherin transcription. This activity requires interaction between...
Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel …
2022年9月5日 · In healthy myocytes, the main cardiac gap junction protein connexin-43 (Cx43) is located at the intercalated disc providing a clear direction of signal spreading across the cardiac tissue. Dislocation of Cx43 to lateral membranes has been detected in numerous cardiac diseases leading to slowed conduction and high propensity for the development ...
Importance of Cx43 for Right Ventricular Function - PMC
2021年1月20日 · In the heart, Cx43 is the most abundantly expressed isoform and is localized in ventricular and atrial cardiomyocytes, but also in endothelial cells, smooth muscle cells and fibroblasts. Cx40 is predominantly expressed in atrial cardiomyocytes, in the cardiac conduction system and is also found in endothelial cells.
Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of …
2017年1月17日 · Studies mostly focused cardiac connexins Cx43 and Cx40 expressed in myocytes, while Cx45 and Cx30.2 have been less investigated, for which main findings are reviewed to highlight their critical contribution in the formation of gap junction channels for ensuring the orchestrated electrical impulse propagation and coordination of atrial and ...
The Connexin43 Carboxyl Terminus and Cardiac Gap Junction …
Connexin 43 (Cx43) is a GJ protein commonly found in excitable tissues in mammals, including humans [9-11]. The ventricular muscle of the heart is particularly enriched for Cx43, where it localizes preferentially to cardiomyocyte longitudinal termini -i.e. the intercalated disk.
Mitochondrial connexin43 and mitochondrial KATP channels …
2023年1月28日 · Connexin43 (Cx43) exits as hemichannels in the inner mitochondrial membrane. We examined how mitochondrial Cx43 and mitochondrial KATP channels affect the occurrence of triggered arrhythmias. To generate cardiac-specific Cx43-deficient (cCx43−/−) mice, Cx43flox/flox mice were crossed with α-MHC (Myh6)-cre+/− mice.