Mitochondria as sensors and regulators of calcium signalling
2012年8月1日 · Mitochondrial Ca2+ uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca2+...
Mitochondria and calcium: from cell signalling to cell death
The observation that mitochondria take up Ca 2+ during physiological Ca 2+ signalling in a variety of cell types leads to four questions: (i) ‘What is the impact of mitochondrial Ca 2+ uptake on mitochondrial function?’. (ii) ‘What is the impact of mitochondrial Ca 2+ …
Calcium Transport and Signaling in Mitochondria - PubMed
2017年3月16日 · Deregulation of either Ca2+ or mitochondrial signaling leads to abnormal function, cell damage or even cell death, thereby contributing to muscle dysfunction or cardiac pathologies. Moreover, altered mitochondrial Ca2+ homeostasis has been linked to metabolic diseases like cancer, obesity, and pulmonary hypertension.
The machineries, regulation and cellular functions of mitochondrial calcium
2018年8月24日 · Calcium ions (Ca 2+) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability, cell...
Regulation of Ca2+ exchanges and signaling in mitochondria
2020年10月1日 · Mitochondrial calcium uniporter (MCU), situated on the inner mitochondrial membrane (IMM), enables uptake of substantial amounts of Ca 2+ from the cytosol during intracellular Ca 2+ signaling events [8].
Calcium, mitochondria and cell metabolism: A functional triangle …
2019年7月1日 · In particular, Ca 2+ signalling has emerged as a key player exploited by mitochondria to tune their activity according with cell demand. The functional interaction between mitochondria and endoplasmic reticulum (ER) deeply impacts on the correct mitochondrial Ca 2+ signal, thus modulating cell bioenergetics and functionality.
Calcium signaling as a mediator of cell energy demand and a …
A schematic representation of the effect of calcium influx and efflux in mitochondria on respiration. Reproduced, with permission, from Llorente Folch et al.83. A rise in [Ca 2+] (c) acts as a positive effector of Ca 2+ ‐binding mitochondrial carriers (CaMCs), including aspartate/glutamate carriers (AGCs) and ATP‐Mg/P i carriers (SCaMCs). Aralar and citrin are mammalian AGCs involved in ...
Calcium signaling around Mitochondria Associated Membranes …
In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca 2+ release and Ca 2+ uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca 2+ signalling, covering the structural and molecular properties of the zones of close contact between these two networks.
Intricate role of mitochondrial calcium signalling in mitochondrial ...
2021年3月1日 · Mitochondrial Ca 2+ plays an important role in the maintenance of mitochondrial dynamics via an alternative switch between fission and fusion; sustained mitochondrial energy metabolism via biogenesis and judicious removal of dysfunctional mitochondria through mitophagy are critical for mitochondrial quality control and homeostasis.
Mitochondrial calcium uniporter complex controls T-cell …
2024年12月2日 · T-cell receptor (TCR)-induced Ca 2+ signals are essential for T-cell activation and function. In this context, mitochondria play an important role and take up Ca 2+ to support elevated bioenergetic demands. However, the functional relevance of the mitochondrial-Ca 2+-uniporter (MCU) complex in T-cells was not fully understood.Here, we demonstrate that TCR activation causes rapid mitochondrial ...
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