Atherosclerosis: Symptoms, Causes & Treatment - Cleveland Clinic
2024年2月15日 · In this stage, a blood clot forms in your artery due to plaque rupture or plaque erosion. Plaque rupture happens when the fibrous cap that covers the plaque breaks open. With plaque erosion, the fibrous cap stays intact, but endothelial …
Arteriosclerosis / atherosclerosis - Symptoms and causes - Mayo Clinic
Atherosclerosis is the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup is called plaque. The plaque can cause arteries to narrow, blocking blood flow. The plaque also can burst, leading to a blood clot.
Mechanisms of Plaque Formation and Rupture
2014年6月6日 · In this review, we discuss mechanisms of atherosclerotic plaque initiation and progression; how plaques suddenly precipitate life-threatening thrombi; and the concepts of plaque burden, activity, and vulnerability.
Characteristics and evaluation of atherosclerotic plaques: an …
The progression of atherosclerosis is accompanied by plaque formation and vascular remodeling. The analysis of various types of plaque characteristics and vascular hemodynamics provides a basis for identifying at-risk plaques and guiding interventions.
Mechanisms of Plaque Rupture - Mechanisms of Vascular …
Mature atherosclerotic plaques are composed of a lipid core that is separated from the vessel lumen by a cap composed of fibrillar collagen. Disruption of this cap exposes the plaque’s underlying thrombogenic core to the bloodstream, resulting in thromboembolism.
Pathophysiology of Atherosclerotic Plaque Development-Contemporary ...
Although key aspects of the process of atherosclerotic plaque development and progression such as local inflammation, LDL oxidation, macrophage activation, and necrotic core formation have already been discovered, many molecular mechanisms affecting this …
Pathophysiology of Atherosclerosis - PMC - PubMed Central (PMC)
In this study, we aimed to review the mechanism of development of atherosclerosis, including endothelial dysfunction, fatty streak formation, fibrous plaque formation, and plaque rupture.
What is Atherosclerosis? - American Heart Association
2024年2月16日 · Atherosclerotic cardiovascular disease (ASCVD) involves plaque buildup in artery walls, which includes conditions such as acute coronary syndrome and peripheral artery disease, and can cause a heart attack, stable or unstable angina, stroke, transient ischemic attack (TIA) or aortic aneurysm.
Atherosclerosis - Nature Reviews Disease Primers
2019年8月16日 · Atherosclerotic plaques can narrow the lumen of the vessel and lead to tissue ischaemia or rupture and trigger the formation of a thrombus.
Atherosclerotic plaque stabilization and regression: a review of ...
2024年1月4日 · Atherosclerotic plaque formation is a complex process involving the migration of LDL-cholesterol (LDL-C) particles (the predominant carrier of apolipoprotein B-100 (apoB)), monocyte adhesion...