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Nomenclature for Mouse Strains - The Jackson Laboratory
Different alleles of a gene may be represented by a superscript to the gene symbol. Nomenclature for a strain with a spontaneous mutation is as follows: C57BL/6J- A w–J. When a mutation is maintained on an inbred strain background by mating homozygotes together, the …
A conditional smoothened (smo) allele on an inbred C57BL/6J …
No homozygous mutant embryos were identified at E9.5, suggesting the null phenotype is at least as severe as that observed on a mixed genetic background. ... This confirmed that the floxed Smo allele is deleterious on the B6 background; of 95 progeny, only 10 were homozygous, rather than the expected 23–24 (chi 2 < 0.003) (Table 1). Table 1.
Know Your Model: A knockout does not always make a null
2020年2月10日 · In contrast to these two ‘null’ Atf2 alleles, mice homozygous for the third allele, Atf2 tm1Glm, are viable on a BALB/c congenic background, though they have decreased body size and immune ...
Attention to Background Strain Is Essential for Metabolic …
Breeding with Flp-recombinase or Cre-recombinase mice in the C57BL/6N background will produce a deletion allele in an isogenic background. Breeding with other strains will result in a knockout mouse on a mixed background.
13: The Effects of Linked Selection - Biology LibreTexts
2023年2月18日 · The effects of background selection are more pronounced in regions of low recombination, where neutral alleles are less able to recombine off the background of deleterious alleles. Thus, under background selection, we also expect to see reduced diversity in regions of lower recombination.
Five Percent Variant Allele Frequency Is a Reliable Reporting …
We report (i) missense variants located in known hotspot positions or truncating/frameshift/splice variants; (ii) coverage for the position of the variant should be ≥1000× with minimum 50 reads for the mutant allele; (iii) background noise level for each variant position ≤0.5% (median value +2 standard deviations).
MSL2 ensures biallelic gene expression in mammals | Nature
2023年11月29日 · Allele-specific bulk and single-cell analyses in mouse neural progenitor cells revealed that, in addition to the targets showing biallelic downregulation, a class of genes transitions from...
Allele - National Human Genome Research Institute
6 天之前 · An allele is one of two or more versions of DNA sequence (a single base or a segment of bases) at a given genomic location. An individual inherits two alleles, one from each parent, for any given genomic location where such variation exists. If the two alleles are the same, the individual is homozygous for that allele.
Detection of allele-specific expression in spatial transcriptomics …
2024年7月8日 · In diploid organisms, allele-specific expression (ASE) refers to the imbalanced expression of the two parental alleles for a given gene. ASE has been well-studied in the context of epigenetic phenomena such as genomic imprinting and X-chromosome inactivation (XCI) [1,2,3], where expression from one allele is silenced.Spatial patterns of ASE have long been observed as a consequence of XCI in ...
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