Effect of mineralocorticoids on acid-base balance - PubMed
Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with …
Effect of Mineralocorticoids on Acid-Base Balance
2014年11月6日 · Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with angiotensin II and other factors to stimulate renal acid excretion.
Acid-base and endocrine effects of aldosterone and angiotensin II ...
Chronic metabolic acidosis (CMA) in human beings is characterized by increased renin-angiotensin-aldosterone (RAA) activity and cortisol secretion as well as nitrogen wasting. The purpose of this study was to examine whether and to what extent increased RAA activity (i.e., angiotensin II or aldoster …
Renal tubular acidosis complicated with hyponatremia due to …
The metabolic acidosis is due to insufficiency of aldosterone, which decreases acid secretion in the kidney. Here, we report a patient with severe hyponatremia and metabolic acidosis that were caused by insufficiency of cortisol but not aldosterone and were successfully treated with hydrocortisone replacement.
Aldosterone Deficiency and Resistance - Endotext - NCBI Bookshelf
2020年11月24日 · Defective aldosterone biosynthesis or action results in various clinical and laboratory test manifestations, such as hypotension, hyponatremia, hyperkalemia, and acidosis. Primary adrenal insufficiency and congenital adrenal hypoplasia are discussed in other chapters.
Acid-base and endocrine effects of aldosterone and angiotensin …
2000年11月1日 · Acidosis coupled to spironolactone-induced hyperglucocorticoidism (either endogenous hypercortisolism or spironolactones acting as glucocorticoid agonists) provides the best explanation for the brisk rise in acid production and excretion in response to spironolactone administration, thereby resulting in only a modest decrease in plasma ...
Hypoaldosteronism | Johns Hopkins Diabetes Guide - Hopkins …
2022年3月5日 · In normal states within the kidney, aldosterone increases sodium reabsorption through opening epithelial sodium channels within the principal cells of the cortical collecting tubule causing the development of an electronegative lumen.
Physiology, Aldosterone - StatPearls - NCBI Bookshelf
2023年5月1日 · Aldosterone's primary function is to act on the late distal tubule and collecting duct of nephrons in the kidney, favoring sodium and water reabsorption and potassium excretion while also contributing to acid-base balance.
Effect of acid-base disturbances on aldosterone secretion in man
2014年3月27日 · We suggest that under acid-base disturbances blood pH may be related, at least, in part to changes in aldosterone in humans. The present study was carried out to elucidate whether changes in blood pH induced by administration of alkalinizing and …
Aldosterone resistance: Structural and functional considerations …
2012年3月24日 · Loss-of-function mutations in two key components of the aldosterone response, the mineralocorticoid receptor and the epithelial sodium channel ENaC, lead to type 1 pseudohypoaldosteronism (PHA1), a rare genetic disease of aldosterone resistance characterized by salt wasting, dehydration, failure to thrive, hyperkalemia and metabolic acidosis.