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  1. Aldose reductase - Wikipedia

    • In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is an enzyme in humans encoded by the gene AKR1B1. It is an cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides, and primarily known for catalyzing the reduction of glucose to sorbitol, the first step in pol… 展开

    Reactions

    Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. The second and last step in the pathway is catalyzed by sorbitol dehydrogenase, … 展开

    Function

    The aldose reductase reaction, in particular the sorbitol produced, is important for the function of various organs in the body. For example, it is generally used as the first step in a synthesis of fructose from glucose; the second step … 展开

    Enzyme structure

    Aldose reductase may be considered a prototypical enzyme of the aldo-keto reductase enzyme superfamily. The enzyme comprises 315 amino acid residues and folds into a β/α-barrel structural motif c… 展开

    Enzyme mechanism

    The reaction mechanism of aldose reductase in the direction of aldehyde reduction follows a sequential ordered path where NADPH binds, followed by the substrate. Binding of NADPH induces a conformational c… 展开

     
  1. Aldolase A - Wikipedia

  2. 25.6: Reactions of Monosaccharides - Chemistry …

    Aldoses can be oxidized to a dicarboxylic acid by dilute nitric acid. Nitric acid is a strong enough oxidizing agent to cause both the aldehyde carbonyl and the -CH 2 OH group to be oxidized to carboxylic acids.

  3. Formose reaction - Wikipedia

  4. 22.6: The Oxidation-Reduction Reactions of Monosaccharides

  5. 12.3: Isomerization at the α-Carbon - Chemistry …

    2022年7月20日 · A reaction (EC 5.1.3.1) in sugar metabolism involves the interconversion of the epimers ribulose-5-phosphate and xylulose-5-phosphate. The enzyme that catalyzes this reaction is called an 'epimerase'.

  6. Aldose Reductase - an overview | ScienceDirect Topics

  7. ALDOSE REDUCTASE: New Insights for an Old Enzyme - PMC

  8. Action of Molybdate Anion on d-Glucosone: Catalytic Conversion …

  9. Amadori rearrangement - Wikipedia