18.4: Alkylation of Aldehydes and Ketones - Chemistry LibreTexts
Overall an α hydrogen is replaced with an alkyl group. This reaction is one of the more important for enolates because a carbon-carbon bond is formed. These alkylations are affected by the …
2017年6月26日 · Here, we show that the synergistic merger of three catalytic processes—photoredox, enamine and hydrogen-atom transfer (HAT) catalysis enables an …
Direct β-Alkylation of Aldehydes via Photoredox Organocatalysis
2014年4月22日 · Direct β-alkylation of saturated aldehydes has been accomplished by synergistically combining photoredox catalysis and organocatalysis. Photon-induced enamine …
Asymmetric α-Alkylation of Aldehydes, Ketones, and Carboxylic …
2013年9月24日 · The α-alkylation of aldehydes and ketones is fundamental to synthetic organic chemistry. Although electrophilic addition to derived enolates is a viable means of achieving …
Direct, enantioselective α-alkylation of aldehydes using ... - Nature
2017年6月26日 · Here, we show that the synergistic merger of three catalytic processes—photoredox, enamine and hydrogen-atom transfer (HAT) catalysis—enables an …
Allylation of aldehydes with various allylation agents
2024年10月1日 · This highly selective intermolecular alkylation was made possible by a novel combination of Pd and enamine, producing the derivatives of alpha-allylic alkylated aldehyde …
ABSTRACT: A mechanism that enables direct aldehyde C−H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This …
Radical-Mediated α- tert -Alkylation of Aldehydes by …
2024年5月28日 · In this study, we present a novel radical-mediated tert -alkylation approach targeting the α-position of aldehydes, enabling the synthesis of complex aliphatic aldehydes.
Mechanism of the Stereoselective α-Alkylation of Aldehydes …
2016年6月6日 · In summary, we have used a combination of conventional photophysical investigations, NMR spectroscopy, and kinetic studies to elucidate the key mechanistic …
Merging Photoredox Catalysis with Organocatalysis: The Direct ...
2008年10月3日 · Specifically, the enantioselective intermolecular α-alkylation of aldehydes has been accomplished using an interwoven activation pathway that combines both the …