Adaptor Proteins - SpringerLink
Examples of this are found in the MAP kinase cascade pathway, where the adaptor proteins IQGAP1 and kinase suppressor of Ras-1 bind to multiple kinases. Consequently, they enable efficient signaling from one kinase to the next.
Insights into the Shc Family of Adaptor Proteins - PMC
Adaptor proteins facilitate protein-protein interactions, which are responsible for intracellular signal propagation as well as organization. The Shc family consists of a group of adaptor proteins that are evolutionary related by some of their shared functional and structural features.
Crk adaptor proteins mediate actin-dependent T cell migration …
S. Gelkop, Y. Babichev, N. Isakov, T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein.
Src family kinases, adaptor proteins and the actin cytoskeleton in ...
2021年6月30日 · Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
Src family kinases, adaptor proteins and the actin cytoskeleton in ...
2021年6月30日 · Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals. Video abstract.
Nck adapter proteins: functional versatility in T cells
2009年2月2日 · Over the past years, a large number of putative Nck interactors have been identified in different cellular systems that point to diverse additional functions of the adapter protein, e.g. in the control of gene expression and proliferation.
Adaptor Proteins - SpringerLink
2020年3月5日 · In order to bind to target proteins, adaptor proteins contain protein-protein interaction domains which recognize specific target motifs (Fig. 1). Through combinations of these domains, adaptor protein can interact with multiple target proteins, potentially forming large signaling complexes.
The indispensability of macrophage adaptor proteins in chronic ...
2023年6月1日 · The Adaptor proteins play a critical role in major chronic inflammatory pathways. Different adaptor proteins and their specific interactions define the type and severity of chronic inflammatory diseases.
The role of adaptor proteins in lymphocyte activation
2004年7月1日 · Research within the last 10 years has provided compelling evidence that adaptor proteins regulate the major pathways of lymphocyte activation. Based upon their differential subcellular localization, transmembrane adaptors and cytosolic adaptors can be distinguished.
Dynamic control of signaling by modular adaptor proteins
2007年4月1日 · Here, I discuss recent analysis of signaling adaptors and scaffold proteins.