ATRA + Arsenic chemo for leukemia, APL | ChemoExperts
ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL) How does ATRA + Arsenic Trioxide work? At diagnosis, APL …
Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
2013年7月11日 · All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of …
Treatment of Acute Promyelocytic Leukemia (APL) - American Cancer Society
Chemotherapy (an anthracycline) plus ATO; ATRA plus ATO is often the preferred treatment in people at lower risk of the leukemia coming back, as it tends to have fewer side effects. …
Management of acute promyelocytic leukemia: updated …
2019年4月11日 · Studies combining ATRA and chemotherapy reported over the last 2 decades have shown a virtual absence of primary resistance, 90% to 95% CR rates, and 85% to 90% …
Treatment of Acute Promyelocytic Leukemia in Adults
2018年9月25日 · Cytotoxic chemotherapy with idarubicin was added to a combination of corticosteroids, ATRA, and ATO to treat 23 high-risk patients in the Australian APML4 study. …
Long-term outcome of acute promyelocytic leukemia treated with all ...
2017年3月9日 · A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly …
Effects of all‐trans retinoic acid (ATRA) in addition to chemotherapy ...
Adding ATRA to chemotherapy probably makes little or no difference to OS. ATRA may be potentially beneficial in combination with decitabine, for older patients (over 60 years) and for …
ATO-ATRA Outperforms Chemo-ATRA in High-Risk APL
2024年6月17日 · First-line treatment with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) plus 2 doses of idarubicin improves event-free survival (EFS) over chemotherapy plus ATRA …
ATRA + ATO vs SoC in high-risk APL: APOLLO trial
2024年7月30日 · The APOLLO trial investigated the efficacy of combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) versus the standard of care, ATRA and chemotherapy …
ATRA/ATO Regimen Improves EFS in Newly Diagnosed, High-risk …
2024年6月15日 · Arsenic trioxide plus all-trans retinoic acid & idarubicin improved EFS vs standard ATRA and anthracycline-based chemotherapy in high-risk APL.