Serotonin: What Is It, Function & Levels - Cleveland Clinic
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter. It also acts as a hormone.
Embracing diversity in the 5-HT neuronal system - Nature
2019年4月4日 · Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core set of genes that establish and maintain this neurotransmitter phenotype and distinguish these...
Physiology, Serotonin - StatPearls - NCBI Bookshelf
2023年7月30日 · Serotonin, or 5-hydroxytryptamine (5-HT), is a neurotransmitter with an integral physiological role in the human body; it regulates various activities, including behavior, mood, memory, and gastrointestinal homeostasis.
Biochemistry, Serotonin - StatPearls - NCBI Bookshelf
2022年10月5日 · Serotonin is a monoamine neurotransmitter that plays a role in several complex biological functions. [1] [2] Its common abbreviation is 5-HT because of its chemical name: 5-hydroxytryptamine.
The role of 5-HT receptors in depression - Molecular Brain
2017年6月24日 · This review addresses the roles that both different gene polymorphisms involved in 5-HT signaling and the different 5-HT receptors (i.e. 5-HT 1A, 5-HT 1B, 5-HT 4, and 5-HT 7) may have in the pathophysiology of depression and the antidepressant response. A streamlined knowledge of these 5-HT signaling-related polymorphisms and receptors may ...
Targeting the 5-HT system: Potential side effects - PubMed
2020年11月15日 · The 5-HT system is targeted by multiple drugs to treat a variety of diseases. Given the homology amongst the 5-HT and neighbouring receptor classes, only few drugs are actually selective for a single target.
Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role …
Serotonin (5-HydroxyTryptamine, [5 -HT]) is a widely distributed monoamine, in the periphery and in the Central Nervous System (CNS) and is involved in numerous physiological and behavioral disorders, such as major depression, anxiety, schizophrenia, mania, autism, obesity, pain, etc. 5-HT is synthesized from the amino acid L-tryptophan (from th...
The 5-Hydroxytryptamine signaling map: an overview of serotonin ...
The neurotransmitter 5-Hydroxytryptamine (5-HT), or serotonin, is most commonly known for its role in the pathophysiology of various neuropsychiatric disorders. However, an abundance of literature based on serotonergic manipulation in animal models has yielded knowledge of the plethora of physiological process directly and indirectly influenced ...
A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System
2017年1月4日 · The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT).
Central 5-HT receptors and their function; present and future
2020年10月15日 · It is well established that two 5-HT receptors, 5-HT 1A and 5-HT 1B, are expressed by 5-HT neurons and function as autoreceptors. 5-HT 1A receptors are located on the soma and dendrites of 5-HT neurons (Verge et al., 1985; Riad et al., 2000), and inhibit the firing of 5-HT neurons and decrease 5-HT release when activated (e.g. Vandermaelen and ...
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