Hymecromone | C10H8O3 | CID 5280567 - PubChem
4-methylumbelliferone is a hydroxycoumarin that is umbelliferone substituted by a methyl group at position 4. It has a role as an antineoplastic agent and a hyaluronic acid synthesis inhibitor. It is functionally related to an umbelliferone.
4-Methylumbelliferone = 98 90-33-5 - MilliporeSigma
4-Methylumbelliferone is primarily used in synthesizing medicinal compounds and as a building block for fluorescent probes. Applications include synthesis of: coumarin triazole derivatives as potential antimicrobial agents.
4-Methylumbelliferone = 98 HPLC, crystalline 5980-33-6
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response.
Umbelliferone: Sources, chemistry and bioactivities review
2017年12月1日 · Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent.
4-甲基伞形酮 ≥98% - Sigma-Aldrich
4-羟甲香豆素主要用于合成药用化合物，并作为荧光探针的构建体。其应用包括用于合成： 作为潜在的抗菌药物的香豆素三唑衍生物。 基于香豆素的荧光传感器，用于Mg 2+ 检测。 吡喃香豆素衍生物，作为抗高血糖和抗血脂异常的药物。
4-Methylumbelliferone (CAS 90-33-5) - Cayman Chem
4-Methylumbelliferone (4-ΜU) is a synthetic coumarin with diverse biological activities. 1, 2, 3 It inhibits hyaluronic acid synthesis in PC3-ML and DU145 cells (IC 50 s = ~0.4 mM for both). 1 4-MU inhibits the growth of PC3-ML, DU145, C4-2B, LNCaP, and LAPC-4 prostate cancer cells (IC 50 s = 0.2-0.4 mM) and invasion and chemotactic motility of ...
4-Methylumbelliferone | 90-33-5 - ChemicalBook
2024年11月29日 · 4-methylumbelliferone (4-MU) is a dietary supplement that inhibits hyaluronic acid (HA) synthesis. HA is a prominent component of the extracellular matrix at many sites of chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous malignancies. 4-MU is an already approved drug in Europe and Asia called ...
4-Methylumbelliferone (4-MU) - APExBIO
4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor. The activation of HAS2 and the over-production of HA are existed in many metastatic tumor cell lines. Increased synthesis of HA is often associated with increased metastatic potential and invasivity in tumor cells.
4-Methylumbelliferone - an overview | ScienceDirect Topics
4-Methylumbelliferone is a fluorescent product formed when the bound enzyme in a chemical reaction with a substrate in a development solution. You might find these chapters and articles relevant to this topic. Richard W. Gantt, Jon S. Thorson, in Methods in Enzymology, 2012.
Formulation of Pharmaceutical Tablets Containing β-Cyclodextrin-4 ...
2023年11月22日 · The present study focuses on the synthesis of the natural product 4-methyl-umbelliferone (4-MU, hymecromone), the preparation, characterization, and biological activity evaluation of 4-MU inclusion complexes with β-cyclodextrin (β-CD), as well as their incorporation into pharmaceutical tablets.