2-Arachidonoylglycerol - Wikipedia
2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB 1 receptor and the primary endogenous ligand for the CB2 receptor. [1][2] It is an ester formed from the omega-6 fatty acid arachidonic acid and glycerol.
2-Arachidonoylglycerol | C23H38O4 | CID 5282280 - PubChem
2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol . It has a role as a human metabolite.
2-Arachidonoylglycerol: A signaling lipid with manifold actions in …
2018年7月1日 · 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB 1 receptor.
2-Arachidonoylglycerol - an overview | ScienceDirect Topics
2-Arachidonoylglycerol is a potent endogenous cannabinoid that binds to both CB1 and CB2 receptors. It is accompanied by 2-palmitoyl-glycerol and 2-linoleoylglycerol in certain organs, but these do not bind to the receptors.
2-Arachidonoylglycerol - an overview | ScienceDirect Topics
2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor.
Parsing the players: 2-arachidonoylglycerol synthesis and degradation ...
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010;65:320–327. doi: 10.1016/j.neuron.2010.01.021.
The endocannabinoid system, anandamide and the regulation of
2003年8月22日 · Anandamide (N -arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of...
From Classical to Alternative Pathways of 2-Arachidonoylglycerol ...
2024年8月4日 · We propose the names of AlterAG-1, -2, and -3 for three pathways sharing an ectocellular localization, allowing them to convert extracellular lysophospholipid mediators into 2-AG, thus inducing typical signaling switches between various G …
Targeting 2‐arachidonoylglycerol signalling in the neurobiology …
In this review, we describe the molecular mechanisms involved in 2-AG signalling in the brain of healthy and stressed animals and discuss how such mechanisms could modulate stress adaptation and susceptibility to depression.
Physiological roles of 2-arachidonoylglycerol, an endogenous
2009年2月18日 · 2-Arachidonoylglycerol is an arachidonic acid-containing monoacylglycerol isolated from the rat brain and canine gut as an endogenous ligand for the cannabinoid receptors (CB1 and CB2). 2-Arachidonoylglycerol binds to both the CB1 receptor, abundantly expressed in the nervous system, and the CB2 receptor, mainly expressed in the immune system ...
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