2,4 Dienoyl-CoA reductase - Wikipedia
2,4 Dienoyl-CoA Reductase from Escherichia coli shares very similar kinetic properties to that of eukaryotes, but differs significantly in both structure and mechanism.
2,4 Dienoyl-CoA Reductase - an overview | ScienceDirect Topics
2,4-Dienoyl-CoA reductase (DECR) and ECI are two auxiliary fatty acid oxidation enzymes required for the full degradation of polyunsaturated fatty acyl-CoAs.
2,4-dienoyl-CoA reductase regulates lipid homeostasis in
2020年5月19日 · To exploit this phenotype, we delineate a subset of proteins consistently associated with ARI resistance and highlight mitochondrial 2,4-dienoyl-CoA reductase (DECR1), an auxiliary enzyme of beta-oxidation, as a clinically relevant biomarker for CRPC.
2,4-dienoyl-CoA reductase regulates lipid homeostasis in ... - Nature
2020年5月19日 · Among the top candidates, 2,4-dienoyl-CoA reductase (DECR1), a mitochondrial enzyme involved in polyunsaturated fatty acid (PUFA) degradation, represents a potential therapeutic target...
Peroxisomal β-oxidation—A metabolic pathway with multiple functions ...
2006年12月1日 · The yeast S. cerevisiae has only peroxisomal 2,4-dienoyl-CoA reductase encoded by the SPS19 gene [85].
Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and …
2019年8月19日 · To shed light on PUFA physiology, we have generated a mouse line defective in mitochondrial dienoyl-CoA reductase (Decr), which is a key enzyme required for β-oxidation of PUFAs.
Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase
2001年8月29日 · Bacterially expressed poly(His)-tagged reductase was active not only towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA. Hence, the reductase does not seem to constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Studies of Human 2,4-Dienoyl CoA Reductase Shed New Light …
2012年8月8日 · Here, we describe the crystal structure of a ternary complex of peroxisomal 2,4-dienoyl CoA reductases (pDCR) with hexadienoyl CoA and NADP, as a prototype for comparison with the mitochondrial 2,4-dienoyl CoA reductase (mDCR) to shed light on the differences between the enzymes from the two organelles at the molecular level.
The Crystal Structure and Reaction Mechanism of Escherichia coli 2,4 ...
The structure presented here of a ternary complex of E. coli 2,4-dienoyl-CoA reductase with NADP + and a fatty acyl-CoA substrate reveals a possible mechanism for substrate reduction and provides details of a plausible electron transfer mechanism involving both flavins and the iron-sulfur cluster. The reaction is initiated by hydride transfer ...
The Mechanism of Dienoyl-CoA Reduction by 2,4-Dienoyl-CoA Reductase …
The chemical mechanism of the 2,4-dienoyl-CoA reductase (EC 1.3.1.34) from rat liver mitochondria has been investigated. This enzyme catalyzes the NADPH-dependent reduction of 2,4-dienoyl-coenzyme A (CoA) thiolesters to the resulting trans -3-enoyl-CoA.
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