Vascular dysfunction as a potential culprit of sarcopenia - PMC
The novel hypothesis is that endothelial dysfunction contributes to sarcopenia by increasing arterial calcification that restricts blood flow and muscle perfusion, which attenuate substrate delivery to skeletal muscle and contributes to atrophy and loss of function.
Vascular dysfunction as a potential culprit of sarcopenia
2021年3月1日 · A common cause of vascular calcification is endothelial dysfunction induced by chronic inflammation and oxidative stress (Incalza et al., 2018), which leads to endothelial cell apoptosis, monocyte adhesion, and decreased production of …
Association of endothelial dysfunction with sarcopenia and …
2021年11月22日 · We aimed to evaluate the association between endothelial dysfunction and sarcopenia, as well as its individual components. Vascular reactivity index (VRI), skeletal muscle index (SMI = skeletal muscle mass/height 2 ), handgrip strength (HGS), and 6-meter usual gait speed (GS) were measured in 95 KT recipients.
Does vascular endothelial dysfunction play a role in physical …
2020年11月6日 · Recent emerging evidence suggests that vascular endothelial dysfunction (VED) may be one such pathophysiological process linking CVDs and physical frailty. Ageing is significantly associated with increased cardiovascular …
Relationship between endothelial function and skeletal muscle …
2018年8月6日 · Endothelial function and skeletal muscle strength had a significant correlation in elderly women, providing additional support for the relevant role of vascular system in sarcopenia. Keywords: Sarcopenia, Endothelial function, EndoPAT.
Vascular endothelial dysfunction may be an early predictor of …
2021年6月1日 · We recently published a systematic review which highlighted early-stage vascular endothelial dysfunction (VED) as one of the potential underlying mechanisms of physical frailty and the role of inflammation in modulating this association.
Does vascular endothelial dysfunction play a role in physical …
2021年5月5日 · Vascular endothelial dysfunction (VED) is the earliest stage of cardiovascular disease (CVD) progression and predicts long-term CVD outcomes. Both these conditions share an elevated inflammatory state as a common pathological factor.
Association of endothelial dysfunction and peripheral arterial …
2024年4月21日 · The main finding of our study was that endothelial dysfunction and PAD, as determined by VRI, endothelial biomarkers and ABI, were associated with sarcopenia in patients with non‐dialysis CKD, indicating the critical role of vascular dysfunction in the development of sarcopenia in CKD.
760 Vascular Endothelial Dysfunction May be an Early Marker of …
Vascular Endothelial Dysfunction (VED) plays a fundamental role in the pathophysiology of a number of cardiovascular disease states, including atherosclerosis, acute coronary syndromes/myocardial infarction, hypertension and heart failure. These cardiovascular disease states have also been linked with physical frailty and sarcopenia.
Differential angiogenesis of bone and muscle endothelium in …
2023年1月31日 · To highlight a possible contribution of organ-specific endothelial cells (ECs), we compare ECs derived from bone and skeletal muscle of the same OA patients. OA bone ECs show a pro-inflammatory...