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Cephalosporins: A Focus on Side Chains and β-Lactam Cross-Reactivity
2018年10月15日 · Cephalosporin cross-reactivity potential is related to the structural R1 side chain, and clinicians should be cognizant of R1 side chain similarities when prescribing alternate β-lactams in allergic individuals or when new cephalosporins are brought to market.
IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity …
2014年11月25日 · Studies regarding the cross-reactivity and tolerability of alternative cephalosporins in large samples of subjects with an IgE-mediated hypersensitivity to cephalosporins are lacking. We sought to evaluate the possibility of using alternative cephalosporins in subjects with cephalosporin allergy who especially require them.
Table 1: Clinically relevant cross-reactivity among beta-lactam ...
Cross-reactivity among beta-lactam antibiotics with similar or identical side chains has been documented. For patients with an immediate allergy to one beta-lactam, it is reasonable to avoid agents with similar side chains. Note: There are no shared side-chains between penicillins and cefazolin, ceftriaxone or ceftazidime.
Cephalosporin Allergy: Current Understanding and Future …
2020年8月31日 · Cephalosporin Cross-Reactivity with Other Beta-Lactams. Patients with cephalosporin allergy appear to be at higher risk for a reaction to other beta-lactam antibiotics because of shared chemical structures (beta-lactam ring, R group side chains).
Cephalosporin Side Chain Cross-reactivity - The Journal of Allergy …
2015年1月5日 · Most of the cross-reactivity information related to side chains is related to amoxicillin and ampicillin. The R-group side chains are identical in amoxicillin and cefadroxil, cefprozil, and cefatrizine. Ampicillin shares side chains with cephalexin, cefaclor, cephradine, cephaloglycin, and loracarbef.
Conclusions: Our data show that cross-reactivity between penicillins and cephalosporins may be as high as 10.9% for first-generation cephalosporins and 1.1% for third-generation cephalosporins, possibly due to the involvement of similar side chains.
Cephalosporin Hypersensitivity: Descriptive Analysis, Cross-Reactivity …
They found a rate of cross-reactivity ranging from 13.3% to 40.1% in cephalosporin hypersensitive patients (for the most majority of them involving ceftriaxone, ceftazidime, cefaclor, and cefazolin) and penicillin reagents, including PPL, MDM, benzylpenicillin, amoxicillin, and ampicillin.
Cross-Reactivity and Tolerability of Cephalosporins in Patients …
2018年9月1日 · In conclusion, our study demonstrated a rate of cross-reactivity among penicillins, cefamandole, and aminocephalosporins around 38%, as well as the tolerability of cefuroxime and ceftriaxone in all subjects with IgE-mediated hypersensitivity to penicillins displaying negative skin tests with these cephalosporins.
Cross-Reactivity and Tolerability of Cephalosporins in Patients …
Cross-reactivity between penicillins and cephalosporins seems to be mainly related to side chain similarity or identity. Subjects with an IgE-mediated hypersensitivity to penicillins could be treated with cephalosporins such as cefuroxime and ceftriaxone …
Cephalosporins' Cross-Reactivity and the High Degree of …
2020年4月25日 · Cross-reactivity between cephalosporins represents, in fact, a well-known threatening event involving cephalosporins with similar or identical R1- or R2-side chains. The present report describes the case of a 79-year-old man who suddenly died after intramuscular administration of ceftriaxone.