Inhibition of acute preterm labor - UpToDate
2024年7月11日 · Tocolysis may enable pregnancy prolongation, at least over the short term, and thus provide time for further in utero maturation and for interventions that may improve infant outcome. This topic will discuss the use of tocolytic medications for …
PROTOCOL: Tocolysis with Nifedipine Background: Nifedipine (Adalat) is a calcium-channel blocker that acts by relaxing smooth muscle. Its main use until now has been in the management of hypertension and angina. When used in preterm labor, it relaxes the uterine wall muscle, decreasing contractions and prolonging the time to delivery.
Nifedipine in the management of preterm labor: a systematic …
2010年7月11日 · Maintenance nifedipine tocolysis was ineffective in prolonging gestation or improving neonatal outcomes when compared with placebo or no treatment. Nifedipine is superior to β 2 -adrenergic-receptor agonists and magnesium sulfate for tocolysis in …
Maximum dose of Nifedipine IR is 160mg/day.1 Onset of tocolysis is at 30 to 60 minutes and institution of a second line of tocolysis should not (1) 1..
fficacy and safety of nifedipine as a to-colytic agent in women with preterm labor. STUDY DESIGN: A systematic review and metaanalysis of . e was no difference between nifedipine and magnesium sulfate in tocolytic efficacy. Nifedipine was associated with significantly fewe.
Nifedipine is a powerful tocolytic, and may occasionally mask early chorioamnionitis presenting as preterm labour. Patients receiving Nifedipine therapy should be observed in hospital for a minimum of 72 hours, and should be followed closely following discharge.
Nifedipine gastrointestinal therapeutic system (GITS) as an alternative to slow-release for tocolysis--tolerance and pharmacokinetic profile. Author(s): Juon, Anna-Mengia; Kühn-Velten, W Nikolaus; Burkhardt, Tilo; Krähenmann, Franziska;
Effect of Maintenance Tocolysis With Nifedipine in Threatened …
2013年1月2日 · Our randomized placebo-controlled trial in women with threatened preterm labor showed that nifedipine maintenance tocolysis for 12 days did not result in a significant reduction in adverse perinatal outcomes when compared with placebo. Our study has several strengths.
Nifedipine for tocolysis - The Lancet Global Health
There is no evidence to suggest that sustained-release nifedipine might have efficacy for tocolysis and there is notable potential for harm: normotensive patients who are exposed to 30 mg of a sustained-release formulation could become hypotensive over several hours.
Nifedipine for Acute Tocolysis of Preterm Labor: A Placebo
2021年7月1日 · Objective: To evaluate the effectiveness of acute nifedipine tocolysis in preventing preterm birth in women in preterm labor.