Dosulepin is used for the treatment of major depressive disorder. There is clear evidence of the efficacy of … 展开

Contraindications include:
• Epilepsy as it can lower the seizure threshold
• TCAs should not be used concomitantly or within 14 days of treatment with monoamine oxidase inhibitors due to … 展开

Common adverse effects:
• Drowsiness
• Extrapyramidal symptoms
• Tremor
• Disorientation… 展开

The symptoms and the treatment of an overdose are largely the same as for the other TCAs. Dosulepin may be particularly toxic in overdose compared to other TCAs. The onset of toxic effects is around 4–6 hours after dosul… 展开

Dosulepin can potentiate the effects of alcohol and at least one death has been attributed to this combination. TCAs potentiate the sedative effects of barbiturates, tranquilizers and CNSTooltip central nervous … 展开