Catalytic asymmetric domino Heck/cross-coupling in the past forty years were broad attraction and applications in the functionalization of C–C π-Bonds 1,2,3,4,5.Relying on a relatively rigid ...

By quenching with HCl (aq.), besides the arylated aldehyde 10, benzaldehyde (12% GC yield) was also detected in the reaction mixture, which was probably formed from the hydrolysis of the isomerized iminium ions. This result suggested that Bn-group was involved in the isomerization of iminium ions, and this process may increase the stability of ...

2.1 Metal Catalysis. In 2022, a novel radical acylation reaction of BCP and aldehydes was developed by Fei Pan and colleagues (Scheme 3) [].With the addition of copper catalyst (CuO) and radical activator (TBHP), the energy barrier of the reaction was overcome to achieve the cross-coupling of BCP and aldehydes.

Taming highly enolizable aldehydes for catalytic asymmetric C–C coupling with nucleophiles remains an elusive challenge compared to widely explored simple alkyl or aryl aldehydes. Herein, we use ThDP-dependent enzymes to realize the direct C–C coupling of highly enolizable 2-phosphonate aldehydes with in situ-generated dynamically reversible nucleophiles (acyl anions). Unlike NHC-mediated ...

The C-N cross-coupling reaction was sharply inhibited or completely quenched, indicating the involvement of a radical process (Fig. 4). Similarly, the addition of K 2 S 2 O 8 as electron (e - ) scavengers or KI as a photo-generated holes (h + ) scavenger uniformly resulted in a dramatic decrease in the yield of 3 , indicating that both electron ...