Ccl2 C-C motif chemokine ligand 2 [ (house mouse)]
2024年11月2日 · Ccl2 gene ablation protects LDL receptor and PON1 double deficient mice from liver injury, oxidative stress and inflammation. Findings provide mechanistic insight into how CCL2-CCR2 signaling in endothelial cells promotes their activation through myosin light chain phosphorylation, resulting in endothelial retraction and enhanced tumor cell ...
CCL2 Gene - GeneCards | CCL2 Protein | CCL2 Antibody
2024年10月1日 · CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CCL2 include Human Immunodeficiency Virus Type 1 and Neural Tube Defects. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.
Ccl2 MGI Mouse Gene Detail - MGI:98259 - C-C motif chemokine …
Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet. Click cells to view annotations. GXD's primary emphasis is on endogenous gene expression during development.
Ccl2 C-C motif chemokine ligand 2 [ Mus musculus (house mouse) ]
2024年10月8日 · Description: RNA profiling data sets generated by the Mouse ENCODE project. Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein-1 are involved in tacrolimus-induced diabetes mellitus. Sun X, et al. Pharmacol Res Perspect, 2023 Jun. PMID 37195045, Free PMC Article.
Disruption of CCL2 in Mesenchymal Stem Cells as an Anti-Tumor …
2023年1月10日 · We found that CCL2 KO MSCs showed anti-tumor function when injected with murine prostate cancer cells into mice. The inhibitory effect was associated with an increase of CD45 + CD11b + mononuclear myeloid cells in tumors. Background: MSCs are known to secrete abundant CCL2, which plays a crucial role in recruiting TAMs, promoting tumor progression.
The corepressors GPS2 and SMRT control enhancer and ... - Cell …
By studying chromatin structure and histone modifications, transcription factor and coregulator dynamics, and eRNA transcription at the mouse Ccl2 locus, they uncover a role of corepressors in controlling enhancer and silencer remodeling linked to inflammatory gene expression.
Inhibition of the CCL2 receptor, CCR2, enhances tumor response …
2020年11月27日 · Here we show across multiple murine tumor and metastasis models that CCR2 antagonism in combination with anti-PD-1 therapy leads to sensitization and enhanced tumor response over anti-PD-1...
Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes
2020年9月17日 · We newly found that in the mouse glioma model, celecoxib decreased mRNA levels of Ccl2, CxcL10 and Cxcr3 but not of Ccr2 and protein expression of CCL2 and CXCL10 in the tumor and peri-tumor.
Diverse activation of microglia by chemokine (C-C motif) ligand 2 ...
2013年7月17日 · Transgenic mice that overexpress CCL2 in the central nervous system (CNS) exhibit a robust accumulation of macrophages and activation of microglia in the brain [8, 9], whereas mice deficient in the CCL2 gene show reduced leukocyte infiltration after autoimmune encephalomyelitis, traumatic brain injury, spinal cord injury and HIV-associated ...
Targeting CCL2-CCR2 signaling pathway alleviates macrophage …
2024年7月17日 · Elevated Ccl2 expression was confirmed in the lungs of COPD mice and was associated with enhanced recruitment and activation of macrophages. Deletion of Ccl2 in knockout mice, as well as treatment with a Ccr2 inhibitor, resulted in protection against CS- and LPS-induced alveolar injury and airway remodeling.