咪唑 CAS#: 288-32-4 - ChemicalBook
5 天之前 · 咪唑衍生物的医学前景 咪唑是一种药物研发的优势骨架，存在于多种药物的核心结构中，科学界已对其进行了广泛的探索。 作为一种良好的药效基团，咪唑可以协同增强药物分子药效，提高体外和体内生物学活性，减小机体生物毒性。
Imidazole as an organocatalyst for the rapid synthesis of 1
3 天之前 · A facile one-pot multicomponent reaction employing aromatic aldehydes, malononitrile, and phthalhydrazide in H2O and EtOH (1:1) mixture at 80ºC has been innovated for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones. This approach stands out for its simplicity, ease of execution, and high efficiency. The reaction employs 20 mol% of imidazole as an …
Self-Assembled Palladium(Ii) Metallacycles Bearing Imidazole
3 天之前 · Abstract. Four unique highly charged palladacycles (Pd1–Pd4) were synthesized in high yield using a linear and rotationally flexible diimidazole donor tecton 4,4'-di(1H-imidazol-1-yl)-1,1'-biphenyl (L1) in combination with cis-blocked [Pd(en)(NO3)2] acceptor and …
Atroposelective synthesis of axially chiral imidazo [1,2-
4 天之前 · The application of the axially chiral imidazole[1,2-a]pyridine scaffold in developing chiral organocatalysts was also explored. Following selective O -methylation with MeI, a two-step process was used to remove the N -benzyl group, yielding the axially chiral amine, which was subsequently coupled with CSCl 2 and ( R,R )- N 1 ,N 1 ...
C–H Functionalization of Imidazo [1,5- - ACS Publications
3 天之前 · Formaldehyde has been used as a solvent and a source of carbon to insert a methylene group for bridging two imidazo[1,5-a]pyridine molecules without using any metal catalysis. This strategy has been extended on other alkyl-, aryl-, and heteroaryl aldehydes as well. This C(sp2)–C(sp3)–H–C(sp2) bond forming reaction proceeds via C(sp2)H functionalization …
Unlocking the Potential of Purine Analogues: A Review on Novel ...
3 天之前 · The purine hybrid 8 substituted diazinyl purine derivatives undergo docking study and shows higher value when interacting with serine kinase, result that explained that imidazole contained purine hybrid 8 substituted diazinyl purine derivatives gives promising score with in the others, with IC 50 value, HL60=64.60± 3.8 μM, A549=80.22±4.1 μM ...
A Novel “Three‐in‐One” Copper‐Based ... - Wiley Online Library
4 天之前 · The coordination structure containing Cu and imidazole rings is the catalytic active center of many proteins and widely exists in organisms, referred to as the various structure consisting of copper and histidine residues, such as blue copper proteins, copper-zinc superoxide dismutase, tyrosinase, laccases, etc. Cu-PrIm nanostructures with a ...
An Overview of Pyrazole-Tetrazole-Based Hybrid Compounds
3 天之前 · Pyrazole and tetrazole are among the most important heterocyclic members of the azole family. Over the past decade, these N-heterocycles and their derivatives have demonstrated specific properties that give them potent applications in several fields such as pharmacology, technology, and agriculture. Combining these two azoles in single hybrid architecture has …
N-乙烯基咪唑 CAS#: 1072-63-5 - ChemicalBook
6 天之前 · ChemicalBook 致力于为化学行业用户提供N-乙烯基咪唑的性质、化学式、分子式、比重、密度,同时也包括N-乙烯基咪唑的沸点、熔点、MSDS、用途、作用、毒性、价格、生产厂家、用途、上游原料、下游产品等信息。
2-甲基咪唑 CAS#: 693-98-1 - ChemicalBook
3 天之前 · ChemicalBook 致力于为化学行业用户提供2-甲基咪唑的性质、化学式、分子式、比重、密度,同时也包括2-甲基咪唑的沸点、熔点、MSDS、用途、作用、毒性、价格、生产厂家、用途、上游原料、下游产品等信息。