Hepcidin - Wikipedia
Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. [6] During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and
Hepcidin: Definition, Function & Tests - Cleveland Clinic
2022年7月28日 · Hepcidin plays an essential role in regulating how your body uses iron. By preventing iron export, hepcidin controls your body’s ability to make hemoglobin and red blood cells. In doing so, hepcidin plays an indirect role in determining the availability of oxygen throughout your entire body.
Physiology, Hepcidin - StatPearls - NCBI Bookshelf
2023年4月17日 · Hepcidin is a peptide hormone produced in the liver that plays a crucial role in iron homeostasis. Iron is an essential part of oxygen transport within the body and is present in hemoglobin, myoglobin, and the electron transport chain.
The Role of Hepcidin in Iron Metabolism - PMC
Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia.
Hepcidin Signaling in Health and Disease: Ironing Out the Details
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels.
Role of hepcidin in the pathophysiology and diagnosis of anemia
This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic role of hepcidin in different types of anemia.
Hepcidin: looking back at two decades of progress | Nature ...
2022年3月10日 · The discovery of hepcidin, the mechanisms of its action and its regulation have transformed our understanding of the pathogenesis of iron-related diseases from anemias to hemochromatosis and have...
Hepcidin, a key regulator of iron metabolism and mediator of …
2003年8月1日 · The key role of hepcidin is confirmed by the presence of nonsense mutations in the hepcidin gene, homozygous in the affected members, in 2 families with severe juvenile hemochromatosis. Recent evidence shows that deficient hepcidin response to iron loading may contribute to iron overload even in the much milder common form of hemochromatosis ...
Hepcidin: Trends in Endocrinology & Metabolism - Cell Press
2024年7月17日 · Hepcidin controls iron concentration in blood plasma as well as organismal iron storage. The hormone acts by impeding iron delivery to plasma from iron-absorbing duodenal enterocytes, iron-storing hepatocytes, and macrophages, that recycle iron from aged erythrocytes.
Hepcidin - PubMed
Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes.