CD44 - Wikipedia
CD44 expression is an indicative marker for effector-memory T-cells. Memory cell proliferation (activation) can also be assayed in vitro with CFSE chemical tagging. In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.
CD44 Gene - GeneCards | CD44 Protein | CD44 Antibody
2024年12月24日 · CD44 (CD44 Molecule (IN Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Hematologic Cancer and Pleural Mesothelioma. Among its related pathways are Glycosaminoglycan metabolism and Innate Immune System.
Differences in CD44 Surface Expression Levels and Function ...
CD44 is a prominent activation marker which distinguishes memory and effector T cells from their naïve counterparts. It also plays a role in early T cell signaling events as it is bound to the lymphocyte-specific protein kinase and thereby enhances ...
The biology and role of CD44 in cancer progression: therapeutic ...
Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the potential for targeting CD44 for cancer therapy.
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a ... - PubMed
2017年3月7日 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a …
2017年3月7日 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …
The normal structure and function of CD44 and its role in neoplasia
CD44 is a transmembrane glycoprotein, the variant isoforms of which are coded for by alternative splicing, with the most prolific isoform being CD44 standard. CD44 is found in a wide variety of tissues including the central nervous system, lung, ...
Frontiers | CD44: molecular interactions, signaling and functions in ...
2015年5月6日 · CD44 is the major surface hyaluronan (HA) receptor implicated in intercellular and cell-matrix adhesion, cell migration and signaling. It is a transmembrane, highly glycosylated protein with several isoforms resulting from alternative gene splicing.
Pathology Outlines - CD44
CD44 IHC (clone 156-3C11, Thermo Fisher Scientific) Comment: CD44 is a marker for cancer stem cell and a biomarker for embryonic stem cells. Surgically resected specimen was fixed in 10% buffered formalin and embedded in paraffin.
CD44: From adhesion molecules to signalling regulators
2003年1月1日 · CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.