DNA repair - Wikipedia
Ionizing radiation such as that created by radioactive decay or in cosmic rays causes breaks in DNA strands. Intermediate-level ionizing radiation may induce irreparable DNA damage (leading to replicational and transcriptional errors needed for neoplasia or may trigger viral interactions) leading to pre-mature aging and cancer.
Studying DNA Double-Strand Break Repair: An Ever-Growing …
DNA double-strand breaks (DSBs) are the most cytotoxic DNA lesions. Their detection, signaling, and repair require a comprehensive cellular response collectively known as the DNA damage response (DDR).
Visualizing the repair of broken DNA in living cells reveals a new ...
2023年8月23日 · DNA double-strand breaks (DSBs) are the most toxic lesions for the cell, as failure to repair one of them leads to either cell death or genomic instability, one of the hallmarks of...
A Clean Break: Scientists Make Surprising Discoveries about DNA Repair
2017年1月6日 · An especially severe type of DNA damage is called a double-strand break, in which the two strands of the DNA double helix break in the same place. Memorial Sloan Kettering molecular biologist Scott Keeney is investigating how cells identify and fix these breaks through a process called homologous recombination, which ensures the DNA segment is ...
PARP1-DNA co-condensation drives DNA repair site assembly to …
2024年2月5日 · DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and how broken DNA is prevented from separating is not understood. Here we uncover that the synapsis of broken DNA is mediated by the DSB sensor protein poly (ADP-ribose) (PAR) polymerase 1 (PARP1).
DNA double-strand breaks: signaling, repair and the cancer
Here we describe recent progress in our understanding of how cells detect and signal the presence and repair of one particularly important form of DNA damage induced by ionizing radiation—the...
RNA-mediated double-strand break repair by end-joining …
2024年9月11日 · Double-strand breaks (DSBs) in DNA are challenging to repair. Cells employ at least three DSB-repair mechanisms, with a preference for non-homologous end joining (NHEJ) over homologous...
Epigenetic Mechanisms in DNA Double Strand Break Repair: A …
2021年7月7日 · The aims of this review are to summarise the role of histone deacetylase and DNA methyltransferase inhibitors involved in DNA double strand break repair and explore their current and future independent use in combination with other DNA repair inhibitors or pre-existing therapies in the clinic.
DNA double-strand break repair: Current Biology - Cell Press
1999年10月21日 · In addition to these main mechanisms, DNA double-strand breaks can be repaired by means of single-strand annealing between adjacent repeated DNA sequences, which involves deletion of the intervening DNA (see Figure 1). This article focuses mainly on nonhomologous end joining, the best-characterized mammalian DNA double-strand break repair ...
Main steps in DNA double-strand break repair: an introduction to ...
2018年1月11日 · DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and chemicals or result from faulty DNA metabolic processes. DNA breaks can also be introduced in a programmed manner, such as during the maturation of the immune system, meiosis, or cancer chemo- or radiotherapy.