ATRA + Arsenic chemo for leukemia, APL | ChemoExperts
ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL) How does ATRA + Arsenic Trioxide work? At diagnosis, APL cells are "trapped" in an immature phase of maturation, do not function normally, and can suppress the growth of good cells in the bone marrow.
Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
2013年7月11日 · All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with...
Treatment of Acute Promyelocytic Leukemia (APL) - American Cancer Society
Chemotherapy (an anthracycline) plus ATO; ATRA plus ATO is often the preferred treatment in people at lower risk of the leukemia coming back, as it tends to have fewer side effects. Chemo or gemtuzumab ozogamicin is more likely to be included in treatment if this risk is higher.
Management of acute promyelocytic leukemia: updated …
2019年4月11日 · Studies combining ATRA and chemotherapy reported over the last 2 decades have shown a virtual absence of primary resistance, 90% to 95% CR rates, and 85% to 90% rates of long-term survival. Best results with ATRA plus chemotherapy are obtained with simultaneous administration of ATRA and anthracycline-containing chemotherapy for induction.
Treatment of Acute Promyelocytic Leukemia in Adults
2018年9月25日 · Cytotoxic chemotherapy with idarubicin was added to a combination of corticosteroids, ATRA, and ATO to treat 23 high-risk patients in the Australian APML4 study. The 5-year DFS was 95% and OS 87% for these patients with high-risk APL.
Long-term outcome of acute promyelocytic leukemia treated with all ...
2017年3月9日 · A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia.
Effects of all‐trans retinoic acid (ATRA) in addition to chemotherapy ...
Adding ATRA to chemotherapy probably makes little or no difference to OS. ATRA may be potentially beneficial in combination with decitabine, for older patients (over 60 years) and for patients who receive therapy for maintenance, but these …
ATO-ATRA Outperforms Chemo-ATRA in High-Risk APL
2024年6月17日 · First-line treatment with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) plus 2 doses of idarubicin improves event-free survival (EFS) over chemotherapy plus ATRA in patients with high...
ATRA + ATO vs SoC in high-risk APL: APOLLO trial
2024年7月30日 · The APOLLO trial investigated the efficacy of combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) versus the standard of care, ATRA and chemotherapy (CHT) in high-risk acute promyelocytic leukaemia (HR-APL).
ATRA/ATO Regimen Improves EFS in Newly Diagnosed, High-risk …
2024年6月15日 · Arsenic trioxide plus all-trans retinoic acid & idarubicin improved EFS vs standard ATRA and anthracycline-based chemotherapy in high-risk APL.