The American Journal of Managed Care8 小时
In Myeloid Neoplasms, Next-Generation Sequencing Can Be Inappropriate—and Money-Wasting
A Yale School of Medicine team has created lists of criteria to help clinicians determine when next-generation sequencing ...
GEN10 天
Novartis, PTC Ink Up-to-$2.9B Huntington’s Disease Collaboration
Novartis will partner with PTC Therapeutics to develop PTC’s PTC518 Huntington's disease program and an unspecified number of related molecules, through an up-to-$2.9 billion exclusive global license ...
Phys.org28 天
Slow editing of protein blueprints leads to cell death, spliceosome study discovers
During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...
EurekAlert!28 天
Slow editing of protein blueprints leads to cell death
USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins ...
Science Daily28 天
Slow editing of protein blueprints leads to cell death
During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...
technologynetworks1 个月
First Blueprint of the Human Spliceosome Published
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...
eLife4 年
Viral-induced alternative splicing of host genes promotes influenza replication
Viral infection induces the expression of numerous host genes that impact the outcome of infection. Here, we show that infection of human lung epithelial cells with influenza A virus (IAV) also ...