gene-expression profiling studies revealed the aberrant expression of products that may provide the rationale for the unprecedented usage of drugs such as tyrosine kinase inhibitors and histone ...

Histone proteins and histone deacetylases (HDAs and HDAC enzymes ... exercise and nutrition. The role of telomeres and telomerase. Telomeres are the protective end caps on chromosomes, and the enzyme ...

Background: Histone deacetylases (HDACs) -2 and -6 are localized in the nucleus and cytoplasm of cells and have been implicated in the development of left ventricular (LV) hypertrophy, cardiac ...

A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, "Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in ...

Many genes whose expression is restricted to neurons in the brain contain a silencer element (RE1/NRSE) that limits transcription in nonneuronal cells by binding the transcription factor REST ...

Purdue Institute for Cancer Research, West Lafayette, Indiana 47907, United States Department of Comparative Pathobiology, West Lafayette, Indiana 47907, United States ...

State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...

The data analysis is rigorous and the experiments performed are appropriate. The findings of the manuscript will expand upon previous findings of a role for histone deacetylase 3 in thymocyte ...

The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates the higher-order structure of ...