In Purdy’s defense, the 49ers have faced a flurry of injuries this season. Names like RB Christian McCaffrey, WR Brandon Aiyuk and T Trent Williams have all missed significant time. In a must ...

Christian McCaffrey averaged 2.9 yards per carry. George Kittle didn't have a catch. All three players, though, made big plays in the second half as the San Francisco 49ers rallied from 17 points ...

The San Francisco 49ers are making a final push to close out a lost season on a strong note. Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update.

Running back Christian McCaffrey ... If everything works out, the 49ers will get a look at Isaac Guerendo in the last two games and then ponder what to do with restricted free agent Jordan ...

Bears The 49ers are 6-9 and out of playoff contention after losing five of their past six games. Their season was torpedoed by injuries and an aging roster. Running back Christian McCaffrey ...

The vibes surrounding the 49ers have been bad since the start of training camp. From the weird holdouts with Brandon Aiyuk and Trent Williams to Christian McCaffrey's calf/Achilles injury.

When the 2020 49ers slank to the finish line amid the ... Everyone understands he has a diminished supporting cast without Christian McCaffrey, Brandon Aiyuk and Trent Williams.

The San Francisco 49ers will roll out a fourth different ... Isaac Guerendo had been pushed into the starting role when RBs Christian McCaffrey and Jordan Mason both suffered injuries in a Week ...

Kyle Juszczyk trolled Christian McCaffrey hard after the San Francisco 49ers running back shared his latest advertisement. Known for his quick wit and closeness with his fellow 49ers teammates ...

Kyle Shanahan's team has been decimated by injuries this season, most notably to wide receiver Brandon Aiyuk, running back Christian McCaffrey, and left tackle Trent Williams. The 49ers still have ...

Bills Terrel Bernard tackles 49ers Christian McCaffrey during first half action of their home game against the San Francisco 49ers in Orchard Park on Dec. 1, 2024. San Francisco 49ers running back ...

15, 2024, in Houston. (AP Photo/Eric Christian Smith) San Francisco 49ers linebacker Dre Greenlaw (57) watches as Los Angeles Rams quarterback Matthew Stafford (9) stands behind center during the ...