deg$color <- ifelse(deg$diffexp_log2fc_Control.vs.cKO > 0, "#A50F15", "#08519C") ggplot(deg, aes(x = diffexp_log2fc_Control.vs.cKO, y = -log10(diffexp_deseq2_pvalue ...

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It has a range of preclinical-stage projects that aim to harness lysosomes’ ability to clear ... lateral sclerosis (ALS), also known as motor neuron disease (MND). In 2020, the biotech was ...

Background: The lysosome plays a vitally crucial role in tumor development and is a major participant in the cell death process, involving aberrant functional and structural changes. However, there ...

School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan 523808, P. R. China Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key ...

These interventions protect against cerebellar neuropathologies, particularly Purkinje neuron mitophagy dysfunction. Thus, PDE9A upregulation considerably exacerbates ataxia associated with CHIP ...

2013). The detrimental effect of GSK-3β activation on dopaminergic neuron survival was further demonstrated in transgenic mice expressing a constitutively active mutant of GSK-3β (Credle et al., 2015) ...

School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China ...

Jan. 17, 2025 — Scientists explored the evolutionary success of leaf beetles, the most diverse herbivores on Earth. They showed that symbioses with bacteria have ... Microbial Cell Factories May ...

Jan. 16, 2025 — Scientists have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of ... Aerobic Exercise: A ...