Cancer-killing T cells have been programmed to have two levels of specificity. First, the T cells have been equipped with a receptor sensitive to a protein that is found only in central nervous ...

This living cell therapy can navigate through the body to a specific organ, addressing what has been a major limitation of CAR-T cancer therapies until now. The technology worked in mice and the ...

UCSF scientists have developed a "molecular GPS" to guide immune cells into the brain and kill tumors without harming healthy tissue. It is the first living cell therapy that can navigate through ...

Researchers investigating ways to reduce exhaustion in cancer-fighting T-cells found that the Golgi apparatus can be used as a simple marker -- more Golgi means a more robust cell. The Golgi ...

I formulated the missing-self hypothesis for natural killer (NK ... I wanted to summarize what was known about NK cell specificity and compare it to T cell specificity, preferably in one sentence.

In a first, scientists have designed immune cells that protect stem cell transplants from being rejected by the body — and they could someday open the door for a cure for diabetes. The new cells ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

The TIME is a dynamic network composed of cancer cells, immune cells, and stromal components. During the early stages of tumorigenesis, the TIME ...

When the immune system overreacts and starts attacking the body, the only option may be to shut the entire system down and risk developing infections or cancer. But now, scientists at UC San Francisco ...

Interaction between genetic factors, estrogen and aging in the development of Th1/TH2 differentiation and subsequent autoimmune diseases in aging women. DC: Dendritic cell; Th: T-helper cell.

The TIME is a dynamic network composed of cancer cells, immune cells, and stromal components. During the early stages of ...