Here we show a unique and previously unrecognized mechanism of drug action in which Et743 subverts normal nucleotide excision repair (NER) by generating lethal DNA breaks during by transcription ...
Sequence variation in human genes is largely confined to single-nucleotide polymorphisms (SNPs) and is valuable in tests of association with common diseases and pharmacogenetic traits. We performed a ...
For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...