引言在生命科学的领域,DNA曾被誉为生命的“天书”,承载了生物体所有的遗传信息。然而,如何解读这本“天书”,从中提取关键的生物学信息,一直是科学界面临的巨大挑战。从基因表达到增强子活性,再到与疾病相关的遗传变异,这些复杂的分子表型背后隐藏着大量的规律 ...
Here we show a unique and previously unrecognized mechanism of drug action in which Et743 subverts normal nucleotide excision repair (NER) by generating lethal DNA breaks during by transcription ...
Sequence variation in human genes is largely confined to single-nucleotide polymorphisms (SNPs) and is valuable in tests of association with common diseases and pharmacogenetic traits. We performed a ...
The "DNA Analysis in the Government Sector - Market Report by Type (Restriction Fragment Length Polymorphism (RFLP), Short ...
Researchers used mitochondrial gene editing to model genetic disorders in mice, revealing profound impacts on brain function, ...
The global nucleotide market size has an estimated market valuation of USD 672.5 Million by 2024 and is projected to grow at ...
Discover how Evo, a groundbreaking DNA-trained AI, is revolutionizing genome creation and what it means for the future of the ...
A study uncovers how cancer cells adapt to low-glucose environments, resisting chemotherapy by conserving uridine nucleotides ...
For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...
An international research collaboration has shed new light on the molecular basis of gene expression, the fundamental ...
Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial ...