1); the RBLOSUM64 matrix performs consistently worse than BLOSUM62 across a wide range of errors per query cutoffs using both Smith-Waterman and BLAST search tools. (An errors-per-query cutoff is ...

prior to BLAST, they had not been applied to biology. Before BLAST, alignment programs used dynamic programming algorithms, such as the Needleman-Wunsch and Smith-Waterman algorithms, that ...