In one pathway, mTOR assembles with its RAPTOR subunit to form mTOR Complex 1 (mTORC1), while in the other pathway RAPTOR is replaced by RICTOR to form mTORC2. mTORC1 activation requires nutrients, ...

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

So, reducing mTOR activity is good for longevity,” he says. One way to effectively switch off mTOR is to cut back on calories ...