Because each LDL particle contains a single molecule of APOB100, which cannot be exchanged or lost to other lipoproteins, plasma APOB100 concentrations reflect the number of circulating ...

Niacin has long been used as an effective lipid-altering therapy, particularly for raising HDL-C and lowering triglyceride levels. In addition, niacin modestly lowers LDL-C levels. LDL-C ...

Soon after starting his laboratory, Zachary Berndsen collected cryoelectron micrographs of hundreds of thousands of LDL ...

Decrease endothelial permeability, gap junctions, endothelial dysfunction and improve endothelial repair: aged garlic. Increase NO, reduce A-II effects, increase EPC's, BP control, reduce ...

Cryo-EM data collection involved single-particle analysis to determine the structural features of LDL, apoB100, and their complexes with the LDLR. Iterative refinement techniques enhanced ...