The quest for VEGF and other factors that promote tumour angiogenesis was initiated many decades ago, and a long and complicated path has led to the development of inhibitors of these molecules as ...

A new mRNA therapy tested in mice may target the root cause of the potentially fatal pregnancy disorder preeclampsia.

New data suggests researchers may have found one of their most promising candidates yet for the next generation in ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Adding the VEGF inhibitor ramucirumab (Cyramza) to the EGFR inhibitor osimertinib (Tagrisso) slowed progression of ...

Recent discoveries in ophthalmology and vascular biology, however, suggest that combined inhibition of VEGF and platelet-derived growth factor (PDGF) may be more beneficial than inhibition of VEGF ...

Adding the VEGF inhibitor ramucirumab (Cyramza) to the EGFR inhibitor osimertinib (Tagrisso) slowed progression of untreated ...

Currently, the only established treatment for acute ischemic stroke is thrombolysis, which is associated with the risk of severe, life-threatening hemorrhage 1,2. Therefore, new approaches in the ...

VEGF inhibitors are widely used in the treatment of metastatic RCC, and pazopanib received FDA approval on the basis of its ability to prolong PFS in metastatic RCC, George noted in his ...

Table 2. Modality of response/resistance to first-line VEGF/VEGFR inhibitors and possible second-line treatment options to be explored. Clinical response to first-line therapy Putative molecular ...