tRNA Ligase as Antifungal Drug Target – Fungal/plant tRNA ligases are essential agents of informational and stress response pathways involving the repair of tRNA breaks (during tRNA splicing) and mRNA ...

We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR ... Activation of MYC is synthetic lethal with IRE1/XBP1 pathway inhibition. We found that ...