Reversible inhibitors work by forming a non-permanent complex with an enzyme. Agents constraining enzymes in a reversible manner come in two main types: competitive and non-competitive. Competitive ...

It was not yet clear whether it was an endopeptidase or a unique type of exopeptidase that ... as we isolated and characterized these new enzyme inhibitors. However, our synthetic expertise ...

Angiotensin converting enzyme inhibitors and angiotensin receptor blockers are commonly used to treat hypertension and/or a range of progressive end-organ diseases. The success of each of these ...

Janus kinase (JAK) inhibitors are a group ... This signals JAK enzymes to add chemical phosphate to their receptors, which attracts another type of protein called signal transducer and activator ...

Hypotension is not a specific side effect with ACE inhibitors; rather, it is a broadening of the physiologic action of these drugs that occurs most commonly when a patient becomes volume contracted.