Reversible inhibitors work by forming a non-permanent complex with an enzyme. Agents constraining enzymes in a reversible manner come in two main types: competitive and non-competitive. Competitive ...
It was not yet clear whether it was an endopeptidase or a unique type of exopeptidase that ... as we isolated and characterized these new enzyme inhibitors. However, our synthetic expertise ...
Janus kinase (JAK) inhibitors are a group ... This signals JAK enzymes to add chemical phosphate to their receptors, which attracts another type of protein called signal transducer and activator ...
Hypotension is not a specific side effect with ACE inhibitors; rather, it is a broadening of the physiologic action of these drugs that occurs most commonly when a patient becomes volume contracted.
Angiotensin converting enzyme inhibitors and angiotensin receptor blockers are commonly used to treat hypertension and/or a range of progressive end-organ diseases. The success of each of these ...